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GAMT Protein (His tag)

GAMT 宿主: 人 宿主: 大肠杆菌(E. Coli) Recombinant > 95 % as determined by reducing SDS-PAGE.
产品编号 ABIN7318555
发货至: 中国
  • 抗原 See all GAMT 蛋白
    GAMT (Guanidinoacetate N-Methyltransferase (GAMT))
    蛋白类型
    Recombinant
    宿主
    • 6
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    资源
    • 6
    • 5
    • 2
    • 1
    大肠杆菌(E. Coli)
    标记
    This GAMT protein is labelled with His tag.
    原理
    Recombinant Human GAMT Protein (His Tag)
    序列
    Met 1-Gly236
    产品特性
    Recombinant Human Guanidinoacetate N-methyltransferase is produced by our E.coli expression system and the target gene encoding Met1-Gly236 is expressed with a 6His tag at the N-terminus, 6His tag at the C-terminus.
    纯度
    > 95 % as determined by reducing SDS-PAGE.
    内毒素水平
    < 1.0 EU per μg as determined by the LAL method.
    Top Product
    Discover our top product GAMT 蛋白
  • 限制
    仅限研究用
  • 状态
    Frozen, Liquid
    缓冲液
    Supplied as a 0.2 μm filtered solution of 20 mM TrisHCl,1 mMDTT, pH 8.0 .
    储存条件
    -20 °C
    储存方法
    Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
  • 抗原
    GAMT (Guanidinoacetate N-Methyltransferase (GAMT))
    别名
    GAMT (GAMT 产品)
    别名
    gamt Protein, zgc:123136 Protein, CCDS2 Protein, PIG2 Protein, TP53I2 Protein, AA571402 Protein, Spintz1 Protein, MGC75698 Protein, GAMT Protein, GMT Protein, guanidinoacetate N-methyltransferase L homeolog Protein, guanidinoacetate N-methyltransferase S homeolog Protein, guanidinoacetate N-methyltransferase Protein, guanidinoacetate methyltransferase Protein, gamt.L Protein, gamt.S Protein, gamt Protein, GAMT Protein, Gamt Protein
    背景

    Background: GAMT is a methyltransferase which belongs to the class I-like SAM-binding methyltransferase superfamily. It contains one RMT2 (arginine N-methyltransferase 2-like) domain and is expressed in liver. GAMT converts guanidoacetate to creatine, using S-adenosylmethionine as the methyl donor. Defects in GAMT are the cause of guanidinoacetate methyltransferase deficiency, which is an autosomal recessive disorder characterized by developmental delay/regression, mental retardation, severe disturbance of expressive and cognitive speech, intractable seizures and movement disturbances, severe depletion of creatine/phosphocreatine in the brain, and accumulation of guanidinoacetic acid in brain and body fluids.

    Synonym: Guanidinoacetate N-methyltransferase, GAMT, PIG2,TP53I2

    分子量
    29.5 kDa
    UniProt
    Q14353
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