K-RAS Protein (His tag)
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- 抗原 See all K-RAS (KRAS) 蛋白
- K-RAS (KRAS) (GTPase Kras (KRAS))
- 蛋白类型
- Recombinant
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宿主
- 人
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资源
- 大肠杆菌（E. Coli）
- 标记
- This K-RAS protein is labelled with His tag.
- 原理
- Recombinant Human KRAS(G12C, N-6His)
- 序列
- Thr2-Cys185(Gly12Cys)
- 产品特性
- Recombinant Human GTPase Kras is produced by our E.coli expression system and the target gene encoding Thr2-Cys185(Gly12Cys) is expressed with a 6His tag at the N-terminus.
- 纯度
- >95 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
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GTPase Kras (KRAS) (AA 1-185) protein (His tag)
KRAS 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 90 % by SDS - PAGE SDS
GTPase Kras (KRAS) (AA 1-186) protein (His tag)KRAS 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 90 % by SDS - PAGE SDS
GTPase Kras (KRAS) (AA 1-189) protein (GST tag)KRAS 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
GTPase Kras (KRAS) (AA 1-188) protein (GST tag)KRAS 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
GTPase Kras (KRAS) (AA 16-125) protein (GST tag)KRAS 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
GTPase Kras (KRAS) (AA 2-185) protein (mFc Tag)KRAS 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
GTPase Kras (KRAS) (AA 2-185) protein (Fc Tag)KRAS 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
GTPase Kras (KRAS) (AA 2-185) protein (His tag)KRAS 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- K-RAS (KRAS) (GTPase Kras (KRAS))
- 别名
- KRAS (KRAS 产品)
- 别名
- wu:fa04e08 Protein, wu:fc14b12 Protein, wu:fc23g10 Protein, wu:fj89d12 Protein, zgc:85725 Protein, Kras2 Protein, c-Ki-ras Protein, p21 Protein, C-K-RAS Protein, CFC2 Protein, K-RAS2A Protein, K-RAS2B Protein, K-RAS4A Protein, K-RAS4B Protein, KI-RAS Protein, KRAS1 Protein, KRAS2 Protein, NS Protein, NS3 Protein, RASK2 Protein, AI929937 Protein, K-ras Protein, Ki-ras Protein, Kras-2 Protein, p21B Protein, ras Protein, k-ras Protein, kras Protein, kras-a Protein, kras-b Protein, rask2 Protein, K-RAS Protein, p21ras Protein, KRAS proto-oncogene, GTPase Protein, v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog Protein, Kirsten rat sarcoma viral oncogene homolog Protein, semicolonial-7 Protein, Ras family protein Protein, GTPase KRas Protein, Kirsten rat sarcoma viral oncogene homolog S homeolog Protein, KRAS Protein, kras Protein, Kras Protein, smco-7 Protein, PGTG_03066 Protein, Tsp_02666 Protein, Tsp_01642 Protein, rask Protein, kras.S Protein
- 物质类
- Viral Protein
- 背景
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Background: K-Ras belongs to the small GTPase superfamily, Ras family. As other members of the Ras family, K-Ras is a GTPase and is an early player in many signal transduction pathways. It is usually tethered to cell membranes because of the presence of an isoprenyl group on its C-terminus. K-Ras functions as a molecular on/off switch. Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation. Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner. Besides essential function in normal tissue signaling, the mutation of a K-Ras gene is an essential step in the development of many cancers. Several germline K-Ras mutations have been found to be associated with Noonan syndrome[4] and cardio-facio-cutaneous syndrome. Somatic K-Ras mutations are found at high rates in Leukemias, colon cancer, pancreatic cancer and lung cancer.
Synonym: Ki-Ras, c-K-ras, KRAS2, RASK2, CFC2
- 分子量
- 23.6 kDa
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