GZMB Protein (His tag)
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- 抗原 See all GZMB 蛋白
- GZMB (Granzyme B (GZMB))
- 蛋白类型
- Recombinant
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This GZMB protein is labelled with His tag.
- 原理
- Recombinant Human Granzyme B/GZMB Protein (His Tag)
- 序列
- Met 1-Tyr 247
- 产品特性
- A DNA sequence encoding the proform of human Granzyme B (NP_004122.1) (Met 1-Tyr 247) was expressed with a C-terminal polyhistidine tag.
- 纯度
- > 97 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product GZMB 蛋白
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Granzyme B (GZMB) (AA 148-247) protein (GST tag)
GZMB 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Granzyme B (GZMB) (AA 21-247) protein (GST tag)GZMB 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Granzyme B (GZMB) protein (His tag)GZMB 宿主: 小鼠 宿主: 人细胞 Recombinant > 85 % as determined by SDS-PAGE
Granzyme B (GZMB) (AA 1-247) protein (GST tag)GZMB 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- GZMB (Granzyme B (GZMB))
- 别名
- Granzyme B/GZMB (GZMB 产品)
- 别名
- CCPI Protein, CGL-1 Protein, CGL1 Protein, CSP-B Protein, CSPB Protein, CTLA1 Protein, CTSGL1 Protein, HLP Protein, SECT Protein, granzyme B Protein, GZMB Protein
- 背景
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Background: Granzyme B, also known as GZMB, is the most prominent member of the granzyme family of cell death-inducing serine proteases expressed in the granules of cytotoxic T lymphocytes (CTLs) and NK cells. Granzyme B enters the target cells depending on another membrane-binding granule protein, perforin, results in the activation of effector caspases and mitochondrial depolarization through caspase-dependent and -independent pathways, and consequently induces rapid cell apoptosis. Over 30 substrates of GZMB have been identified including the key substrate caspase-3, ICAD and Bid. GZMB is suggested to protect the host by lysing cells bearing on their surface 'nonself' antigens such as bacterial and viral infected-cells and tumor cells, and accordingly plays an essential role in immunosurveillance.
Synonym: CCPI,CGL-1,CGL1,CSP-B,CSPB,CTLA1,CTSGL1,HLP,SECT
- 分子量
- 27 kDa
- NCBI登录号
- NP_004122
- 途径
- Apoptosis, Caspase Cascade in Apoptosis
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