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Glypican 3 Protein (GPC3) (His tag)

GPC3 宿主: 小鼠 宿主: 人细胞 Recombinant >95 % as determined by reducing SDS-PAGE.
产品编号 ABIN7320888
发货至: 中国
  • 抗原 See all Glypican 3 (GPC3) 蛋白
    Glypican 3 (GPC3)
    蛋白类型
    Recombinant
    宿主
    • 22
    • 6
    • 5
    • 4
    • 1
    小鼠
    资源
    • 25
    • 7
    • 2
    • 2
    • 1
    • 1
    人细胞
    标记
    This Glypican 3 protein is labelled with His tag.
    原理
    Recombinant Mouse Glypican-3/GPC3/OCI5 (C-6His)
    序列
    Gln25-Met557
    产品特性
    Recombinant Mouse Glypican-3 is produced by our Mammalian expression system and the target gene encoding Gln25-Met557 is expressed with a 6His tag at the C-terminus.
    纯度
    >95 % as determined by reducing SDS-PAGE.
    内毒素水平
    < 1.0 EU per μg as determined by the LAL method.
    Top Product
    Discover our top product GPC3 蛋白
  • 限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Please refer to the printed manual for detailed information.
    缓冲液
    Lyophilized from a 0.2 μm filtered solution of PBS, 5 % Trehalose, pH 7.4.
    储存条件
    4 °C,-20 °C,-80 °C
    储存方法
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • 抗原
    Glypican 3 (GPC3)
    别名
    Glypican-3/GPC3/OCI5 (GPC3 产品)
    别名
    GPC3 Protein, sgb Protein, dgsx Protein, sdys Protein, sgbs Protein, oci-5 Protein, sgbs1 Protein, DGSX Protein, GTR2-2 Protein, MXR7 Protein, OCI-5 Protein, SDYS Protein, SGB Protein, SGBS Protein, SGBS1 Protein, Glypican-3 Protein, glypican 3 Protein, gpc3 Protein, GPC3 Protein, Gpc3 Protein
    背景

    Background: Glypican-3/GPC3 is a member of the glypican family. It belongs to the glypican family and is highly expressed in lung, liver, and kidney. It is a heparan sulfate proteoglycan, which is overexpressed in various neoplasms such as hepatocellular carcinoma, malignant melanoma, and testicular yolk sac tumor, and plays an important role in cell growth and differentiation. GPC3 function is tissue dependent. In some tissues, GPC3 acts as a tumor suppressor gene, whereas in others, it acts as an oncofetal protein. GPC3 is a reliable marker for hepatocellular carcinoma. The sensitivity and specificity exceeds both alpha-fetoprotein and hepatocyte-paraffin1. GPC3 immunohistochemistry can aid in the differentiation of testicular germ cell tumors, being expressed in all yolk sac tumors but not in seminomas. GPC3 expression has also been identified in some squamous cell carcinomas of the lung and clear cell carcinomas of the ovary. Glypican-3 is currently regarded as a tumor marker and potential target for immunotherapy.

    Synonym: Glypican-3, GTR2-2, Intestinal protein OCI-5, MXR7, GPC3, OCI5

    分子量
    61.6 kDa
    UniProt
    Q8CFZ4
    途径
    Glycosaminoglycan Metabolic Process
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