ERN1 蛋白
-
- 抗原 See all ERN1 蛋白
- ERN1 (Endoplasmic Reticulum To Nucleus Signaling 1 (ERN1))
- 蛋白类型
- Recombinant
- 生物活性
- Active
-
宿主
- 人
-
资源
- Baculovirus infected Insect Cells
- 原理
- Recombinant Human ERN1/IRE1 Protein (aa 465-977)(Active)
- 序列
- Pro 465-Leu 977
- 产品特性
- A DNA sequence encoding the human ERN1 (O75460-1) (Pro 465-Leu 977) was expressed and purified with two additional amino acids (Gly & Pro ) at the N-terminus.
- 纯度
- > 80 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
- Biological Activity Comment
- 1.Kinase activity untested 2. Measured by its nuclease activity to cleave Xbp1 single stem-loop mini-substrate.
- Top Product
- Discover our top product ERN1 蛋白
-
Endoplasmic Reticulum To Nucleus Signaling 1 (ERN1) (AA 401-500) protein (GST tag)
ERN1 宿主: 人 宿主: 小麦胚 Recombinant WB, AA, AP, ELISA
Endoplasmic Reticulum To Nucleus Signaling 1 (ERN1) (AA 1-70) protein (GST tag)ERN1 宿主: 人 宿主: 小麦胚 Recombinant WB, AA, AP, ELISA
Endoplasmic Reticulum To Nucleus Signaling 1 (ERN1) (AA 465-977) (Active) protein (GST tag,His tag)ERN1 宿主: 人 宿主: Baculovirus infected Insect Cells Recombinant > 80 % as determined by reducing SDS-PAGE. Active
Endoplasmic Reticulum To Nucleus Signaling 1 (ERN1) protein (Myc-DYKDDDDK Tag)ERN1 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
-
- 限制
- 仅限研究用
-
- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile 20 mM Tris, 500 mM NaCl, 10 % glycerol, pH 7.4
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
-
- 抗原
- ERN1 (Endoplasmic Reticulum To Nucleus Signaling 1 (ERN1))
- 别名
- ERN1/IRE1 (ERN1 产品)
- 别名
- IRE1 Protein, IRE1P Protein, IRE1a Protein, hIRE1p Protein, 9030414B18Rik Protein, AI225830 Protein, C85377 Protein, Ire1a Protein, Ire1alpha Protein, Ire1p Protein, RGD1559716 Protein, Ern1 Protein, Ire1 Protein, Ire1b Protein, sb:eu1005 Protein, zgc:109932 Protein, endoplasmic reticulum to nucleus signaling 1 Protein, endoplasmic reticulum to nucleus signaling 2 Protein, endoplasmic reticulum (ER) to nucleus signalling 1 Protein, serine/threonine-protein kinase/endoribonuclease IRE1 Protein, endoplasmic reticulum (ER) to nucleus signalling 2 Protein, ERN1 Protein, ERN2 Protein, Ern1 Protein, LOC524719 Protein, Ern2 Protein, ern1 Protein
- 背景
-
Background: Trypsin-3; also known as Trypsin III; brain trypsinogen; Serine protease 3 and PRSS3; is a secreted protein which belongs to the peptidase S1 family. Trypsin-3 / PRSS3 is expressed is in pancreas and brain. It contains one peptidase S1 domain. Trypsin-3 / PRSS3 can degrade intrapancreatic trypsin inhibitors that protect against CP. Genetic variants that cause higher mesotrypsin activity might increase the risk for chronic pancreatitis (CP). A sustained imbalance of pancreatic proteases and their inhibitors seems to be important for the development of CP. The trypsin inhibitor-degrading activity qualified PRSS3 as a candidate for a novel CP susceptibility gene. Trypsin-3 / PRSS3 has been implicated as a putative tumor suppressor gene due to its loss of expression; which is correlated with promoter hypermethylation; in esophageal squamous cell carcinoma and gastric adenocarcinoma.
Synonym: hIRE1p;IRE1;IRE1a;IRE1P
- 分子量
- 58.3 kDa
- 途径
- ER-Nucleus Signaling, Unfolded Protein Response
-
