Coxsackie Adenovirus Receptor Protein (Fc Tag)
-
- 抗原 See all Coxsackie Adenovirus Receptor (CXADR) 蛋白
- Coxsackie Adenovirus Receptor (CXADR) (Coxsackie Virus and Adenovirus Receptor (CXADR))
- 蛋白类型
- Recombinant
-
宿主
- 小鼠
-
资源
- 人细胞
- 标记
- This Coxsackie Adenovirus Receptor protein is labelled with Fc Tag.
- 原理
- Recombinant Mouse CXADR/CAR Protein (Fc Tag)
- 序列
- Leu20-Gly237
- 产品特性
- Recombinant Mouse CXADR is produced by our Mammalian expression system and the target gene encoding Leu20-Gly237 is expressed with a Fc tag at the C-terminus.
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product CXADR 蛋白
-
-
- 限制
- 仅限研究用
-
- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
-
- 抗原
- Coxsackie Adenovirus Receptor (CXADR) (Coxsackie Virus and Adenovirus Receptor (CXADR))
- 别名
- CXADR/CAR (CXADR 产品)
- 别名
- CAR Protein, CAR4/6 Protein, HCAR Protein, Car1 Protein, car Protein, cb331 Protein, fb76g12 Protein, wu:fb76g12 Protein, 2610206D03Rik Protein, AU016810 Protein, AW553441 Protein, MCAR Protein, MCVADR Protein, hcar Protein, xCAR Protein, CXADR Protein, CXADR, Ig-like cell adhesion molecule Protein, coxsackie virus and adenovirus receptor Protein, CXADR, Ig-like cell adhesion molecule L homeolog Protein, CXADR Protein, Cxadr Protein, cxadr Protein, cxadr.L Protein
- 背景
-
Background: Coxsackievirus and adenovirus receptor homolog(CAR), also known as CXADR, is a type I transmembrane glycoprotein that belongs to the CTX family of the Ig superfamily. CXADR has monomer subunit that interacts with LNX, BAIAP1, DLG4, PRKCABP, TJP1 and CTNNB1. It also interacts with MPDZ and JAML. CXADR composed of of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. CXADR also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair.
Synonym: Coxsackievirus and adenovirus receptor homolog,CAR,Cxadr,CVB3 BP,MCVADR
- 分子量
- 51 kDa
- UniProt
- P97792
- 途径
- Cell-Cell Junction Organization
-