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CPLX2 Protein (His tag)

CPLX2 宿主: 人 宿主: 大肠杆菌(E. Coli) Recombinant > 90 % as determined by reducing SDS-PAGE.
产品编号 ABIN7317462
发货至: 中国
  • 抗原 See all CPLX2 蛋白
    CPLX2 (Complexin 2 (CPLX2))
    蛋白类型
    Recombinant
    宿主
    • 4
    • 2
    • 1
    • 1
    资源
    • 3
    • 2
    • 2
    • 1
    大肠杆菌(E. Coli)
    标记
    This CPLX2 protein is labelled with His tag.
    原理
    Recombinant Human Complexin-2/CPLX2 Protein (His Tag)
    序列
    Asp 2-Lys 134
    产品特性
    A DNA sequence encoding the human CPLX2 (Q6PUV4-1) (Asp 2-Lys 134) was expressed, with a polyhistide tag at the N-terminus.
    纯度
    > 90 % as determined by reducing SDS-PAGE.
    Top Product
    Discover our top product CPLX2 蛋白
  • 限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Please refer to the printed manual for detailed information.
    缓冲液
    Lyophilized from sterile PBS, pH 7.4
    储存条件
    4 °C,-20 °C,-80 °C
    储存方法
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • 抗原
    CPLX2 (Complexin 2 (CPLX2))
    别名
    Complexin-2/CPLX2 (CPLX2 产品)
    别名
    921-L Protein, CPX-2 Protein, CPX2 Protein, Hfb1 Protein, AI413745 Protein, AW492120 Protein, MGC68923 Protein, MGC79539 Protein, complexin 2 Protein, complexin 2 L homeolog Protein, complexin-2 Protein, CPLX2 Protein, Cplx2 Protein, cplx2.L Protein, cplx2 Protein, LOC750228 Protein
    背景

    Background: Complexin-2 (CPLX2), a member of the complexin/synaphin family, is a soluble pre-synaptic protein believed to regulate neurotransmitter release from pre-synaptic terminals. Complexins are soluble proteins that regulate the activity of soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complexes necessary for vesicle fusion. Complexins are unable to bind to monomeric SNARE proteins but bind with high affinity to ternary SNARE complexes and with lower affinity to target SNARE complexes. Complexin 1 (CX1) and complexin 2 (CX2) are presynaptic proteins that modulate neurotransmitter release and are used as markers of inhibitory and excitatory synapses, respectively. CPLX2 is localized in pre-synaptic terminals in mature brain. The G71-P89 region of CPLX2 is essential and sufficient for preferential axonal distribution. CPLX2 participates in the Ca(2+)-sensitive regulatory pathway for zymogen granule exocytosis. Complexin-2 is a key player in normal neurological function, and its downregulation could lead to changes in neurotransmitter release sufficient to cause significant behavioural abnormalities such as depression. It is involved in synaptogenesis and the modulation of neurotransmitter release.

    Synonym: 921-L,CPX-2,CPX2,Hfb1

    分子量
    16.8 kDa
    途径
    Synaptic Vesicle Exocytosis
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