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C5A 蛋白

C5a 宿主: 人 宿主: 大肠杆菌(E. Coli) Recombinant > 95 % as determined by reducing SDS-PAGE.
产品编号 ABIN7319677
发货至: 中国
  • 抗原 See all C5A (C5a) 蛋白
    C5A (C5a) (Complement Component 5a (C5a))
    蛋白类型
    Recombinant
    宿主
    • 5
    • 4
    • 4
    • 2
    • 2
    资源
    • 15
    • 1
    大肠杆菌(E. Coli)
    原理
    Recombinant Human Complement C5a Protein
    序列
    Thr678-Arg751
    产品特性
    Recombinant Human C5a is produced by our E.coli expression system and the target gene encoding Thr678-Arg751 is expressed.
    纯度
    > 95 % as determined by reducing SDS-PAGE.
    内毒素水平
    < 1.0 EU per μg as determined by the LAL method.
    Top Product
    Discover our top product C5a 蛋白
  • 限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Please refer to the printed manual for detailed information.
    缓冲液
    Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
    储存条件
    4 °C,-20 °C,-80 °C
    储存方法
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • 抗原
    C5A (C5a) (Complement Component 5a (C5a))
    别名
    Complement C5a (C5a 产品)
    别名
    C5a Protein, C5b Protein, CPAMD4 Protein, Hc Protein, RGD1561905 Protein, complement C5 Protein, C5 Protein
    背景

    Background: Human Complement 5a (C5a) is an enzymatically generated glycoprotein that belongs to a family of structurally and functionally related proteins known as anaphylatoxins. C5a is a 74 amino acid (aa) peptide that is created by the activity of C5a convertase on the C5 α-chain. Human C5a has four α-helices plus three intrachain disulfide bonds that create a triple loop structure. Human C5a is 60 % and 54 % aa identical to mouse and rat C5a, respectively. C5a binds to a signaling G-protein coupled receptor (C5aR/CD88) and a nonsignaling GPCR termed C5L2. Activation of Cd88 results in neutrophil chemotaxis and endothelial cell activation. It also triggers an oxidative burst in macrophages and neutrophils, and induces release of histamine in basophils and mast cells.

    Synonym: Complement C5, C5a anaphylatoxin, C5a,CPAMD4,ECLZB,C5Da

    分子量
    8.4 kDa
    UniProt
    P01031
    途径
    Complement System, Carbohydrate Homeostasis
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