CSF3R 蛋白
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- 抗原 See all CSF3R 蛋白
- CSF3R (Colony Stimulating Factor 3 Receptor (Granulocyte) (CSF3R))
- 蛋白类型
- Recombinant
- 生物活性
- Active
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宿主
- 人
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资源
- HEK-293 Cells
- 原理
- Recombinant Human G-CSFR/CD114 Protein (Active)
- 序列
- Met 1-Pro 621
- 产品特性
- The mature form of human G-CSF receptor (NP_000751.1) extracellular domain (Met 1-Pro 621) with five aminio acids at the C-terminus was expressed and purified.
- 纯度
- > 85 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Biological Activity Comment
- Measured by its ability to inhibit GCSF-induced proliferation of NFS60 mouse myeloid cells.The ED50 for this effect is typically 2-8 μg/mL.
- Top Product
- Discover our top product CSF3R 蛋白
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Colony Stimulating Factor 3 Receptor (Granulocyte) (CSF3R) (AA 25-627) protein (His tag)
CSF3R 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Colony Stimulating Factor 3 Receptor (Granulocyte) (CSF3R) (AA 26-626) protein (His tag)CSF3R 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Colony Stimulating Factor 3 Receptor (Granulocyte) (CSF3R) (AA 25-622) protein (His tag)CSF3R 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Colony Stimulating Factor 3 Receptor (Granulocyte) (CSF3R) (AA 25-621) protein (His tag)CSF3R 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE.
Colony Stimulating Factor 3 Receptor (Granulocyte) (CSF3R) protein (Fc Tag)CSF3R 宿主: 人 宿主: 人细胞 Recombinant >95 % as determined by reducing SDS-PAGE.
Colony Stimulating Factor 3 Receptor (Granulocyte) (CSF3R) (AA 25-621) (Active) protein (Fc Tag)CSF3R 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
Colony Stimulating Factor 3 Receptor (Granulocyte) (CSF3R) (AA 25-621) (Active) protein (His tag,AVI tag,Biotin)CSF3R 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- CSF3R (Colony Stimulating Factor 3 Receptor (Granulocyte) (CSF3R))
- 别名
- G-CSFR/CD114 (CSF3R 产品)
- 背景
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Background: Granulocyte Colony Stimulating Factor Receptor (G-CSFR), also known as CD114, which belongs to the cytokine receptor superfamily, is a cell surface receptor for colony stimulating factor 3 (CSF3). It is a critical regulator of granulopoiesis. This type I membrane protein has a composite structure consisting of an immunoglobulin(Ig)-like domain, a cytokine receptor-homologous (CRH) domain and three fibronectin type III (FNIII) domains in the extracellular region. Mutations in the G-CSF receptor leading to carboxy-terminal truncation transduce hyperproliferative growth responses, and are implicated in the pathological progression of severe congenital neutropenia (SCN) to acute myelogenous leukemia (AML). Additionally, autocrine/paracrine stimulation of G-CSFR may be important in the biology of solid tumors, including metastasis.
Synonym: CD114,CSF3R,G-CSF R,GCSFR
- 分子量
- 69.0 kDa
- NCBI登录号
- NP_000751
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