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CNTF 蛋白

This Recombinant CNTF protein is expressed in 大肠杆菌(E. Coli).
产品编号 ABIN7319650
发货至: 中国

Quick Overview for CNTF 蛋白 (ABIN7319650)

抗原

See all CNTF 蛋白
CNTF (Ciliary Neurotrophic Factor (CNTF))

蛋白类型

Recombinant

生物活性

Active

宿主

  • 19
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资源

  • 26
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大肠杆菌(E. Coli)

纯度

> 95 % as determined by reducing SDS-PAGE.
  • 原理

    Recombinant Human CNTF Protein (Active)

    序列

    Ala2-Met200

    产品特性

    Recombinant Human Ciliary Neurotrophic Factor is produced by our E.coli expression system and the target gene encoding Ala2-Met200 is expressed.

    内毒素水平

    < 1.0 EU per μg as determined by the LAL method.

    Biological Activity Comment

    Measured in a cell proliferation assay using TF-1 human erythroleukemic cells. The ED50 for this effect is 25 ng/ml.
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    Conjugate His tag
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  • 限制

    仅限研究用
  • 状态

    Lyophilized

    溶解方式

    Please refer to the printed manual for detailed information.

    缓冲液

    Lyophilized from a 0.2 μm filtered solution of PBS,1 mM Cysteine,PH7.4.

    储存条件

    4 °C,-20 °C,-80 °C

    储存方法

    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • 抗原

    CNTF (Ciliary Neurotrophic Factor (CNTF))

    别名

    CNTF

    背景

    Background: Ciliary Neurotrophic Factor (CNTF) is a potent survival factor for neurons and oligodendrocytes. CNTF has also been shown to prevent the degeneration of motor axons after axotomy. CNTF is highly conserved across species and exhibits cross-species activities. Human and rat CNTF share approximately 83 % homology in their protein sequence. CNTF is structurally related to IL6, IL11, LIF and OSM. All of these four helix bundle cytokines share gp130 as a signal transducing subunit in their receptor complexes. CNTF, like FGF acidic, FGF basic, and PD-ECGF (platelet-derived endothelial cell growth factor), does not possess a signal sequence that would allow secretion of the factor by classical secretion pathways. The mechanism underlying the release of CNTF is unknown.

    Synonym: Ciliary Neurotrophic Factor, CNTF

    分子量

    22.93 kDa

    UniProt

    P26441

    途径

    JAK/STAT Signaling
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