CD84 Protein (CD84) (His tag)
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- 抗原 See all CD84 蛋白
- CD84
- 蛋白类型
- Recombinant
- 生物活性
- Active
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宿主
- 小鼠
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资源
- HEK-293 Cells
- 标记
- This CD84 protein is labelled with His tag.
- 原理
- Recombinant Mouse SLAMF5/CD84 Protein (His Tag)(Active)
- 序列
- Met 1-Val 221
- 产品特性
- A DNA sequence encoding the mouse CD84 isoform 1 (Q18PI6-1) extracellular domain (Met 1-Val 221) was expressed, with a polyhistidine tag at the C-terminus.
- 纯度
- > 97 % as determined by SDS-PAGE
- 内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
- Biological Activity Comment
- Measured by its ability to bind biotinylated recombinant human SH2D1A in a functional ELISA.
- Top Product
- Discover our top product CD84 蛋白
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- CD84
- 别名
- SLAMF5/CD84 (CD84 产品)
- 别名
- RGD1564553 Protein, A130013D22Rik Protein, CDw84 Protein, SLAMF5 Protein, LY9B Protein, hCD84 Protein, mCD84 Protein, CD84 molecule Protein, CD84 antigen Protein, Cd84 Protein, CD84 Protein
- 背景
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Background: The CD2 family receptors are type I transmembrane glycoproteins belonging to immunoglobulin (Ig) superfamily characterized by a membrane-proximal Ig constant 2 (C2) domain and a membrane-distal variable (V) domain that is responsible for ligand recognition. CD84, also known as LY9B and SLAMF5, is a homophilic member of the SLAM (signaling lymphocyte activation molecule) subfamily of the CD2 family. The SLAM family receptorsmediate signal transduction through the interaction of its ITSM (immunoreceptor tyrosine-based switch motifs) in the intracellular region and the SH2 domain of adaptor molecules SAP (SLAM-associated protein) and EAT-2 (EWS-activated transcript 2), and accordingly modulate both adaptive and innate immune responses. The CD84-CD84 interaction was independent of its cytoplasmic tail. Thus, CD84 is its own ligand and acts as a costimulatory molecule. CD84 is expressed on cells from almost all hematopoietic lineages and on CD34+ hematopoietic progenitor cells, suggesting that CD84 serves as a marker for committed hematopoietic progenitor cells.
Synonym: SLAM family member 5, Cd84, Leukocyte differentiation antigen CD84, Signaling lymphocytic activation molecule 5, CD84, Ly-9B, SLAMF5, CD84 antigen, CD84 Molecule, SLAM family member 5
- 分子量
- 24 kDa
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