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CD6 Protein (CD6) (Fc Tag)

CD6 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by reducing SDS-PAGE. Active
产品编号 ABIN7317120
发货至: 中国
  • 抗原 See all CD6 蛋白
    CD6
    蛋白类型
    Recombinant
    生物活性
    Active
    宿主
    • 6
    • 4
    • 2
    • 1
    资源
    • 7
    • 3
    • 2
    • 1
    HEK-293 Cells
    标记
    This CD6 protein is labelled with Fc Tag.
    原理
    Recombinant Human CD6/TP120 (Fc Tag)(Active)
    序列
    Met 1-Glu398
    产品特性
    A DNA sequence encoding the human CD6 (NP_006716.3) (Met1-Glu398) was expressed with the Fc region of human IgG1 at the C-terminus.
    纯度
    > 95 % as determined by reducing SDS-PAGE.
    内毒素水平
    < 1.0 EU per μg as determined by the LAL method.
    Biological Activity Comment
    Measured by the ability of the immobilized protein to support the adhesion of Jurkat human acute T cell leukemia cells.When 8x10E4 cells/well are added to CD6-Fc coated plates (10 μg/mL, 100 μL/well), approximately >70% will adhere after 60 minutes at 37°C.
    Top Product
    Discover our top product CD6 蛋白
  • 限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Please refer to the printed manual for detailed information.
    缓冲液
    Lyophilized from sterile PBS, pH 7.4
    储存条件
    4 °C,-20 °C,-80 °C
    储存方法
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • 抗原
    CD6
    别名
    CD6/TP120 (CD6 产品)
    别名
    TP120 Protein, OX52 Protein, CD6 antigen Protein, CD6 molecule Protein, Cd6 molecule Protein, Cd6 Protein, CD6 Protein
    背景

    Background: T-cell differentiation antigen CD6, also known as TP120 and CD6, is a single-pass type I membrane protein which contains three SRCR domains. CD6 / TP120 is a cell surface glycoprotein expressed primarily on T cells, it may function as a costimulatory molecule and may play a role in autoreactive immune responses. CD6 / TP120 is expressed by thymocytes, mature T-cells, a subset of B-cells known as B-1 cells, and by some cells in the brain. CD6 ligand termed CD166 (previously known as activated leukocyte cell adhesion molecule, ALCAM ) has been identified and shown to be expressed on activated T cells, B cells, thymic epithelium, keratinocytes, and in rheumatoid arthritis synovial tissue. CD6 / TP120 binds to activated leukocyte cell adhesion molecule ( CD166 ), and is considered as a costimulatory molecule involved in lymphocyte activation and thymocyte development. CD6 / TP120 partially associates with the TCR / CD3 complex and colocalizes with it at the center of the mature immunological synapse (IS) on T lymphocytes. During thymic development CD6-dependent signals may contribute both to thymocyte survival, and to the overall functional avidity of selection in both man and mouse.

    Synonym: TP120

    分子量
    67.3 kDa
    NCBI登录号
    NP_006716
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