CD1b Protein (CD1B) (Fc Tag)
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Quick Overview for CD1b Protein (CD1B) (Fc Tag) (ABIN7317475)
抗原
See all CD1b (CD1B) 蛋白蛋白类型
宿主
资源
纯度
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标记
- This CD1b protein is labelled with Fc Tag.
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原理
- Recombinant Human CD1B/CD1A Protein (Fc Tag)
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序列
- Met 1-Ser 303
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产品特性
- A DNA sequence encoding the human CD1B (NP_001755) (Met1-Ser 303) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
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过滤
- 0.2 μm filtered
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内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
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Biological Activity Comment
- Not validated for activity
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CD1b (CD1B) (AA 1-333) protein (GST tag)
CD1B 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AP, AA
CD1b (CD1B) (AA 18-303) protein (His tag)CD1B 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 90 % SDS
CD1b (CD1B) (AA 18-303) protein (His-IF2DI Tag)CD1B 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. ELISA, WB
CD1b (CD1B) protein (Myc-DYKDDDDK Tag)CD1B 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
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Lyophilized from sterile PBS, pH 7.4
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization. -
储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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有效期
- 12 months
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- CD1b (CD1B)
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别名
- CD1B/CD1A
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背景
- CD1,CD1A,CD1B,R1,CD1B contains 1 Ig-like (immunoglobulin-like) domain and belongs to the CD1 family. CD1 family members are transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. During protein synthesis and maturation, they bind endogenous lipids that are replaced by lipid or glycolipid antigens when the proteins are internalized and pass through endosomes, before trafficking back to the cell surface. CD1B localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail, and requires vesicular acidification to bind lipid antigens.. It is expressed on cortical thymocytes, epidermal Langerhans cells, dendritic cells, on certain T-cell leukemias, and in various other tissues. CD1B is an antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.
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分子量
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Calculated MW: 58.6 kDa
Observed MW: 59-69 kDa
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基因ID
- 910
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NCBI登录号
- NP_001755
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UniProt
- P29016
抗原
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