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CD16 Protein (CD16) (His tag)

CD16 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE Active
产品编号 ABIN7194703
发货至: 中国
  • 抗原 See all CD16 蛋白
    CD16
    蛋白类型
    Recombinant
    生物活性
    Active
    宿主
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    小鼠
    资源
    • 5
    • 2
    • 2
    HEK-293 Cells
    标记
    This CD16 protein is labelled with His tag.
    原理
    Recombinant Mouse CD16 Protein (His Tag)(Active)
    序列
    Met 1-Thr 215
    产品特性
    A DNA sequence encoding the mouse FCGR3 (P08508-1) extracellular domain (Met 1-Thr 215) was fused with a polyhistidine tag at the C-terminus.
    纯度
    > 95 % as determined by SDS-PAGE
    内毒素水平
    < 1.0 EU per μg of the protein as determined by the LAL method.
    Biological Activity Comment
    Measured by its binding ability in a functional ELISA.Immobilized mouse FCGR3-His at 10 μg/ml (100 μl/well) can bind biotinylated human IgG1The EC50 of biotinylated human IgG1 is 0.12-0.28 μg/ml.
    Top Product
    Discover our top product CD16 蛋白
  • 限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Please refer to the printed manual for detailed information.
    缓冲液
    Lyophilized from sterile PBS, pH 7.4
    储存条件
    4 °C,-20 °C,-80 °C
    储存方法
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • 抗原
    CD16
    别名
    CD16 (CD16 产品)
    别名
    Fcgr3 Protein, Fcgr3a Protein, CD16 Protein, FCGR3 Protein, FCGR3@ Protein, CD16b Protein, FCG3 Protein, FCR-10 Protein, FCRIII Protein, FCRIIIb Protein, FcRIII Protein, Fc fragment of IgG, low affinity IIa, receptor Protein, Fc fragment of IgG, low affinity IIIa, receptor (CD16a) Protein, Fc fragment of IgG receptor IIIb Protein, Fc fragment of IgG receptor IIIa Protein, Fc receptor, IgG, low affinity III Protein, Fc-gamma RIII Protein, Fcgr2a Protein, FCGR3A Protein, FCGR3B Protein, Fcgr3 Protein, FCGR3 Protein
    背景

    Background: Fc receptors bind the most common class of antibody, IgG, are called Fc gamma receptors (FcγR). FcγR is divided into three classes, Fc γ RI (CD64), Fc γ RII (CD32), and Fc γ RIII (CD16). CD16 protein is a multifunctional, low/intermediate affinity receptor, which belongs to the immunoglobulin superfamily. It is found on the surface of natural killer cells, neutrophil polymorphonuclear leukocytes, monocytes and macrophages. Mouse CD16 is encoded by a single gene, while, human CD16 is expressed as two distinct forms (CD16a/FcγRIIIa and CD16b/FcγRIIIb) encoded by two different highly homologous genes in a cell type-specific manner. CD16 is involved in phagocytosis, secretion of enzymes, inflammatory mediators, antibody-dependent cellular cytotoxicity (ADCC), and clearance of immune complexes.

    Synonym: CD16 Protein, Mouse

    分子量
    22.6 kDa
    途径
    Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
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