CSNK2A1/CK II alpha 蛋白
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- 抗原 See all CSNK2A1/CK II alpha (CSNK2A1) 蛋白
- CSNK2A1/CK II alpha (CSNK2A1) (Casein Kinase 2 alpha 1 (CSNK2A1))
- 蛋白类型
- Recombinant
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宿主
- 小鼠
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资源
- Baculovirus infected Insect Cells
- 原理
- Recombinant Mouse CSNK2A1/CK2A1 Protein (Active)
- 序列
- Met1-Gln391
- 产品特性
- A DNA sequence encoding the mouse CAMK4 CSNK2A1 (Q60737) (Met1-Gln391) was expressed and purified with two additional amino acids (Gly & Pro) at the N-terminus.
- 纯度
- > 95 % as determined by SDS-PAGE
- 内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
- Biological Activity Comment
- Kinase activity untested
- Top Product
- Discover our top product CSNK2A1 蛋白
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Casein Kinase 2 alpha 1 (CSNK2A1) (AA 6-344) protein (His-IF2DI Tag)
CSNK2A1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % by SDS-PAGE gel analyses ELISA, WB
Casein Kinase 2 alpha 1 (CSNK2A1) protein (His tag)CSNK2A1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 90 % by SDS - PAGE SDS
Casein Kinase 2 alpha 1 (CSNK2A1) (AA 1-391) protein (GST tag)CSNK2A1 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AA, AP
Casein Kinase 2 alpha 1 (CSNK2A1) (AA 1-100) protein (GST tag)CSNK2A1 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AA, AP
Casein Kinase 2 alpha 1 (CSNK2A1) (Active) protein (GST tag)CSNK2A1 宿主: 人 宿主: Baculovirus infected Insect Cells Recombinant > 93 % as determined by reducing SDS-PAGE. Active
Casein Kinase 2 alpha 1 (CSNK2A1) (Active) protein (GST tag,His tag)CSNK2A1 宿主: 小鼠 宿主: Baculovirus infected Insect Cells Recombinant > 85 % as determined by SDS-PAGE Active
Casein Kinase 2 alpha 1 (CSNK2A1) (AA 8-350), (partial) protein (His-SUMO Tag)CSNK2A1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 90 % SDS
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile 20 mM Tris, 500 mM NaCl, 10 % glycerol, pH 7.4
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- CSNK2A1/CK II alpha (CSNK2A1) (Casein Kinase 2 alpha 1 (CSNK2A1))
- 别名
- CSNK2A1/CK2A1 (CSNK2A1 产品)
- 别名
- CK2A2 Protein, CSNK2A1 Protein, CK2A1 Protein, CKII Protein, CSNK2A3 Protein, CK2A Protein, Ck2a Protein, BmCK2a Protein, wu:fi38e04 Protein, wu:fi38h03 Protein, csnk2a1 Protein, CK-II Protein, CK2 Protein, Ckiialpha Protein, Csnk2a1-rs4 Protein, ck2a1 Protein, casein kinase 2 alpha 2 Protein, casein kinase 2 alpha 1 Protein, casein kinase 2 alpha subunit Protein, casein kinase 2, alpha 1 polypeptide Protein, CK2 protein kinase alpha 2 Protein, casein kinase II alpha subunit Protein, Casein kinase II alpha subunit Protein, casein kinase 2, alpha 1 polypeptide S homeolog Protein, CSNK2A2 Protein, CSNK2A1 Protein, ck2a Protein, Ck2a Protein, csnk2a1 Protein, cka2 Protein, Ckiialpha Protein, CK2A1 Protein, Csnk2a1 Protein, csnk2a1.S Protein
- 背景
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Background: Casein kinase II subunit alpha, also known as CK II alpha, CSNK2A1 and CK2A1, is a member of the protein kinase superfamily, Ser / Thr protein kinase family and CK2 subfamily. Casein kinase II (CSNK2A1) is a serine / threonine protein kinase that phosphorylates acidic proteins such as casein. This kinase is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. Casein kinase II (CSNK2A1) is a constitutively active, ubiquitously expressed serine / threonine protein kinase that is thought to have a regulatory function in cell proliferation, cell differentiation and apoptosis. CSNK2A1 functions as a tetrameric complex consisting of two regulatory beta-subunits and two catalytic units (alpha and alpha') in a homomeric or heteromeric conformation. Whilst the alpha- and alpha'-subunits are catalytically identical, proteins that regulate CSNK2A1, such as cdc2 and Hsp90, preferentially bind to the alpha and not the alpha'-subunit. CSNK2A1 can phosphorylate a number of key intracellular signaling proteins implicated in tumor suppression (p53 and PTEN) and tumorigenesis (myc, jun, NF-kappaB). CSNK2A1 is also thought to influence Wnt signaling via beta-catenin phosphorylation and the PI 3-K signaling pathway via th phosphorylation of Akt.
Synonym: Csnk2a1-rs4
- 分子量
- 45.3 kDa
- UniProt
- Q60737
- 途径
- SARS-CoV-2 Protein Interactome
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