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Calsequestrin 蛋白

CASQ1 宿主: 人 宿主: 大肠杆菌(E. Coli) Recombinant > 80 % as determined by reducing SDS-PAGE.
产品编号 ABIN7317197
发货至: 中国
  • 抗原 See all Calsequestrin (CASQ1) 蛋白
    Calsequestrin (CASQ1) (Calsequestrin 1 (CASQ1))
    蛋白类型
    Recombinant
    宿主
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    资源
    • 4
    • 3
    • 2
    • 1
    大肠杆菌(E. Coli)
    原理
    Recombinant Human Calsequestrin-1/CASQ1 Protein
    序列
    Gln35-Asp396
    产品特性
    A DNA sequence encoding the mature form of human CASQ1 (P31415) (Gln35-Asp396) was expressed with a N-terminal Met.
    纯度
    > 80 % as determined by reducing SDS-PAGE.
    Top Product
    Discover our top product CASQ1 蛋白
  • 限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Please refer to the printed manual for detailed information.
    缓冲液
    Lyophilized from sterile 50 mM Tris, 10 % glycerol, pH 7.5
    储存条件
    4 °C,-20 °C,-80 °C
    储存方法
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • 抗原
    Calsequestrin (CASQ1) (Calsequestrin 1 (CASQ1))
    别名
    Calsequestrin-1/CASQ1 (CASQ1 产品)
    别名
    CASQ Protein, PDIB1 Protein, casq1 Protein, CSQ Protein, CSQ-1 Protein, CSQ1 Protein, sCSQ Protein, zgc:154027 Protein, asph Protein, casq Protein, casq1.L Protein, pdib1 Protein, bZ1G18.2 Protein, zgc:100957 Protein, calsequestrin 1 Protein, Calsequestrin-1 Protein, calsequestrin 1b Protein, calsequestrin 1 S homeolog Protein, calsequestrin 1a Protein, CASQ1 Protein, casq1 Protein, Casq1 Protein, casq1b Protein, casq1.S Protein, casq1a Protein
    背景

    Background: Calsequestrin-1 is an isoform of calsequestrin. Calsequestrin is a calcium-binding protein of the sarcoplasmic reticulum. It helps hold calcium in the cisterna of the sarcoplasmic reticulum after a muscle contraction, even though the concentration of calcium in the sarcoplasmic reticulum is much higher than in the cytosol. Two forms of calsequestrin have been identified: Calsequestrin-2 and Calsequestrin-1. Calsequestrin-1 is found in fast skeletal muscle. The release of calsequestrin-bound calcium (through a calcium release channel) triggers muscle contraction. The active protein is not highly structured, more than 50 % of it adopting a random coil conformation. When calcium binds there is a structural change whereby the alpha-helical content of the protein increases from 3 to 11 %. Both forms of calsequestrin are phosphorylated by casein kinase 2, but the cardiac form is phosphorylated more rapidly and to a higher degree. Calsequestrin-1 is also secreted in the gut where it deprives bacteria of calcium ions.

    Synonym: CASQ,PDIB1,VMCQA

    分子量
    41.8 kDa
    UniProt
    P31415
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