APEX1 蛋白
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- 抗原 See all APEX1 蛋白
- APEX1 (Apurinic/Apyrimidinic Endonuclease 1 (APEX1))
- 蛋白类型
- Recombinant
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宿主
- 人
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资源
- 大肠杆菌（E. Coli）
- 原理
- Recombinant Human APE1/APE Protein
- 序列
- Pro2-Leu318
- 产品特性
- Recombinant Human Apurinic-Apyrimidinic Endonuclease 1 is produced by our E.coli expression system and the target gene encoding Pro2-Leu318 is expressed.
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
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- Discover our top product APEX1 蛋白
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Apurinic/Apyrimidinic Endonuclease 1 (APEX1) (AA 1-318) protein (GST tag)
APEX1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Apurinic/Apyrimidinic Endonuclease 1 (APEX1) (AA 97-195) protein (His-IF2DI Tag)APEX1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Apurinic/Apyrimidinic Endonuclease 1 (APEX1) (AA 1-318) protein (T7 tag)APEX1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 90 % by SDS - PAGE SDS
Apurinic/Apyrimidinic Endonuclease 1 (APEX1) (AA 1-318) protein (His tag)APEX1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Apurinic/Apyrimidinic Endonuclease 1 (APEX1) (AA 219-318) protein (GST tag)APEX1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Apurinic/Apyrimidinic Endonuclease 1 (APEX1) (AA 32-318) protein (His tag)APEX1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 90 % SDS
Apurinic/Apyrimidinic Endonuclease 1 (APEX1) (Transcript Variant 1) proteinAPEX1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- 限制
- 仅限研究用
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- 状态
- Frozen, Liquid
- 缓冲液
- Supplied as a 0.2 μm filtered solution of 10 mM HEPES, 100 mM KCl, 50 % Glycerol, pH 7.4.
- 储存条件
- -20 °C
- 储存方法
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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- 抗原
- APEX1 (Apurinic/Apyrimidinic Endonuclease 1 (APEX1))
- 别名
- APE1/APE (APEX1 产品)
- 别名
- apex1 Protein, MGC76280 Protein, MGC79645 Protein, MGC78928 Protein, APE Protein, APE1 Protein, APEN Protein, APEX Protein, APX Protein, HAP1 Protein, REF1 Protein, Apex Protein, REF-1 Protein, BAP1 Protein, apex1a Protein, hm:zehn1532 Protein, wu:fc13d11 Protein, zgc:66204 Protein, Ref-1 Protein, apurinic/apyrimidinic endodeoxyribonuclease 1 Protein, APEX nuclease (multifunctional DNA repair enzyme) 1 Protein, APEX nuclease (multifunctional DNA repair enzyme) 1 L homeolog Protein, DNA-(apurinic or apyrimidinic site) lyase Protein, apurinic/apyrimidinic endonuclease 1 Protein, APEX1 Protein, apex1 Protein, apex1.L Protein, CNG03640 Protein, CNH01280 Protein, nth Protein, Spirs_4119 Protein, Palpr_0103 Protein, Apex1 Protein
- 背景
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Background: Apurinic-Apyrimidinic Endonuclease 1 (APE1) is required for efficient DNA base excision repair. When the DNA glycosylase remove the damaged bases, APE1 cleaves the AP site to allow resynthesis and ligation to complete repair. APE1 stimulates the DNA binding activity of many transcription factors, which participate in cancer promotion and progression. APE1 regulates the redox state of multiple transcription factors, such as c-Jun, c-Fos, NF-kB, p53. APEN is also involved in calcium-dependent down-regulation of PTH expression.
Synonym: DNA-(Apurinic or Apyrimidinic Site) Lyase, APEX Nuclease, APEN, Apurinic-Apyrimidinic Endonuclease 1, AP Endonuclease 1, APE-1REF-1, Redox Factor-1, APEX1, APE, APE1, APEX, APX, HAP1, REF1
- 分子量
- 35.6 kDa
- UniProt
- P27695
- 途径
- DNA Damage Repair, Chromatin Binding, Cell RedoxHomeostasis, Smooth Muscle Cell Migration, Positive Regulation of Response to DNA Damage Stimulus
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