ANGPTL3 Protein (His tag)
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- 抗原 See all ANGPTL3 蛋白
- ANGPTL3 (Angiopoietin-Like 3 (ANGPTL3))
- 蛋白类型
- Recombinant
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宿主
- 小鼠
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资源
- 人细胞
- 标记
- This ANGPTL3 protein is labelled with His tag.
- 原理
- Recombinant Mouse ANGPTL3 Protein (His Tag)
- 序列
- Ser17-Thr206
- 产品特性
- Recombinant Mouse ANGPTL3 is produced by our Mammalian expression system and the target gene encoding Ser17-Thr206 is expressed with a 6His tag at the C-terminus.
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product ANGPTL3 蛋白
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Angiopoietin-Like 3 (ANGPTL3) (AA 17-219) protein (His-Avi Tag)
ANGPTL3 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Angiopoietin-Like 3 (ANGPTL3) protein (His-Avi Tag,Biotin)ANGPTL3 宿主: 人 宿主: HEK-293 Cells Recombinant > 95% as determined by Tris-Bis PAGE
Angiopoietin-Like 3 (ANGPTL3) (AA 361-460) protein (GST tag)ANGPTL3 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Angiopoietin-Like 3 (ANGPTL3) (AA 17-460) protein (GST tag)ANGPTL3 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Angiopoietin-Like 3 (ANGPTL3) protein (Fc Tag)ANGPTL3 宿主: 人 宿主: 人细胞 Recombinant >95 % as determined by reducing SDS-PAGE.
Angiopoietin-Like 3 (ANGPTL3) (AA 17-221) protein (His tag)ANGPTL3 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Angiopoietin-Like 3 (ANGPTL3) (AA 17-220) protein (His tag)ANGPTL3 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by reduced SDS-PAGE.
Angiopoietin-Like 3 (ANGPTL3) (AA 17-220) (Active) protein (His tag,AVI tag,Biotin)ANGPTL3 宿主: 人 宿主: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- ANGPTL3 (Angiopoietin-Like 3 (ANGPTL3))
- 别名
- ANGPTL3 (ANGPTL3 产品)
- 别名
- fb60e11 Protein, fb66h02 Protein, wu:fb60e11 Protein, wu:fb66h02 Protein, zgc:111943 Protein, ANGPTL3 Protein, LOC100230785 Protein, ANG-5 Protein, ANGPT5 Protein, ANL3 Protein, FHBL2 Protein, hypl Protein, angiopoietin-like 3 Protein, angiopoietin like 3 Protein, angptl3 Protein, ANGPTL3 Protein, Angptl3 Protein
- 背景
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Background: Angiopoietin-likeProtein 3 (ANGPTL3) is a secreted glycoprotein that is structurally related to the angiopoietins. Mature mouse ANGPTL3 contains an N-terminalcoiled coil domain and a C-terminalfibrinogen-likedomain. Within the Nterminalfragment, mouse ANGPTL3 shares 83 % and 92 % aa sequence identity with human and rat ANGPTL3, respectively. ANGPTL3 is expressed in the liver from early in development through adulthood. ANGPTL3 directly inhibits lipoprotein lipase (LPL) and endothelial lipase (EL), enzymesresponsible for hydrolyzing circulating triglycerides and HDL phospholipids. This activity requires a putative heparin-bindingmotif which is N-terminalto thecoiled coil domain. Proteolytic removal of the fibrinogen-likedomain from the N-terminalfragment serves to activate ANGPTL3 and increase its ability toinhibit LPL in vitro and function in vivo. ANGPTL3 promotes an increase in circulating triglyceride levels without altering VLDL or HDL secretion oruptake. ANGPTL3 expression in vivo is up-regulatedby LXR agonists anddown-regulatedby insulin, leptin, and agonists of TRβ or PPARβ. ANGPTL3, secreted by fetal liver cells, also promotes the expansion of hematopoietic stem cells.
Synonym: Angiopoietin-related Protein 3, Angiopoietin-like protein 3, Angptl3
- 分子量
- 22.7 kDa
- UniProt
- Q9R182
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