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Aconitase 1 Protein (ACO1) (His tag)

ACO1 宿主: 人 宿主: Baculovirus infected Insect Cells Recombinant > 95 % as determined by reducing SDS-PAGE.
产品编号 ABIN7194099
发货至: 中国
  • 抗原 See all Aconitase 1 (ACO1) 蛋白
    Aconitase 1 (ACO1)
    蛋白类型
    Recombinant
    宿主
    • 10
    • 4
    • 2
    资源
    • 11
    • 2
    • 2
    • 1
    Baculovirus infected Insect Cells
    标记
    This Aconitase 1 protein is labelled with His tag.
    原理
    Recombinant Human ACO1/irp1 Protein (His Tag)
    序列
    Met 1-Lys 889
    产品特性
    A DNA sequence encoding the human ACO1 (P21399) (Met 1-Lys 889) was expressed, with a polyhistidine tag at the N-terminus.
    纯度
    > 95 % as determined by reducing SDS-PAGE.
    内毒素水平
    < 1.0 EU per μg as determined by the LAL method.
    Top Product
    Discover our top product ACO1 蛋白
  • 限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Please refer to the printed manual for detailed information.
    缓冲液
    Lyophilized from sterile 50 mM Tris, 100 mM NaCl, pH 8.0, 10 % glycerol, 2 mM DTT
    储存条件
    4 °C,-20 °C,-80 °C
    储存方法
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • 抗原
    Aconitase 1 (ACO1)
    别名
    ACO1/irp1 (ACO1 产品)
    别名
    ACONS Protein, IREB1 Protein, IREBP Protein, IREBP1 Protein, IRP1 Protein, Acon1 Protein, Ratireb Protein, ratireb Protein, Aco1 Protein, AI256519 Protein, Aco-1 Protein, Irebp Protein, Irp1 Protein, aconitase 1 Protein, aconitase 1, soluble Protein, aconitase 1 L homeolog Protein, ACO1 Protein, Aco1 Protein, aco1.L Protein
    背景

    Background: Aconitase 1(ACO1) or IRP1 is one member of the aconitase family that contains a diverse group of iron-sulphur(Fe-S) isomerases and two types of iron regulatory protein. Aconitase exits in two forms: one is soluble and the other is mitochondrial. ACO1 is the soluble existing form, and the mitochondrial form is ACO2. Residues from all three N-terminal domains and the larger C-terminal domain contribute to the active site region. When the enzyme is activated, it gains an additional iron atom. ACO1 can assume two different functions in cells, depending on different conditions. During iron scarcity or oxidative stress, ACO1 binds to mRNA stem-loop structures called iron responsive elements to modulate the translation of iron metabolism genes. In iron-rich conditions, ACO1 binds an iron-sulfur cluster to function as a cytosolic aconitase. 

    Synonym: ACONS;HEL60;IREB1;IREBP;IREBP1;IRP1

    分子量
    101 kDa
    UniProt
    P21399
    途径
    Transition Metal Ion Homeostasis
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