ACPP Protein (His tag)
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- 抗原 See all ACPP 蛋白
- ACPP (Acid Phosphatase, Prostate (ACPP))
- 蛋白类型
- Recombinant
- 生物活性
- Active
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This ACPP protein is labelled with His tag.
- 原理
- Recombinant Human Prostatic Acid Phosphatase/ACPP Protein (His Tag)(Active)
- 序列
- Met 1-Lys 382
- 产品特性
- A DNA sequence encoding the human ACPP (NP_001127666.1) (Met 1-Lys 382) was fused with a polyhistidine tag at the C-terminus.
- 纯度
- > 97 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Biological Activity Comment
- Measured by its ability to cleave a substrate, pNitrophenyl phosphate (pNPP). The specific activity is >100,000 pmol/min/μg.
- Top Product
- Discover our top product ACPP 蛋白
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Acid Phosphatase, Prostate (ACPP) (AA 310-418) protein (GST tag)
ACPP 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Acid Phosphatase, Prostate (ACPP) (AA 1-386) protein (GST tag)ACPP 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Acid Phosphatase, Prostate (ACPP) protein (His tag)ACPP 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 98 % as determined by SDS-PAGE
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- ACPP (Acid Phosphatase, Prostate (ACPP))
- 别名
- Prostatic Acid Phosphatase/ACPP (ACPP 产品)
- 别名
- 5'-NT Protein, ACP-3 Protein, ACP3 Protein, PAP Protein, AMAP2 Protein, CENTB3 Protein, DDEF2 Protein, PAG3 Protein, Pap-alpha Protein, SHAG1 Protein, A030005E02Rik Protein, FRAP Protein, Lap Protein, Ppal Protein, Acpp11 Protein, RNACPP11 Protein, pap Protein, ACPP Protein, acp-3 Protein, acp3 Protein, acpt Protein, acid phosphatase, prostate Protein, ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 Protein, prostatic acid phosphatase Protein, prostatic acid phosphatase, putative Protein, acid phosphatase, prostate S homeolog Protein, ACPP Protein, ASAP2 Protein, Acpp Protein, CpipJ_CPIJ004002 Protein, Smp_016640 Protein, acpp.S Protein
- 背景
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Background: Prostatic acid phosphatase (PAP, or ACPP), also known as prostatic specific acid phosphatase (PSAP), is an enzyme produced by the prostate. As a non-specific phosphomonoesterase, Prostatic acid phosphatase synthetized and secreted into seminal plasma under androgenic control. The enzyme is a dimer of molecular weight around 100 kDa. Prostatic acid phosphatase is a clinically important protein for its relevance as a biomarker of prostate carcinoma. Furthermore, it has a potential role in fertilization. The major action of PAP is to dephosphorylate macromolecules with the help of catalytic residues (His(12) and Asp(258)) that are located in the cleft between two domains. Cellular prostatic acid phosphatase (cPAcP), an authentic tyrosine phosphatase, is proposed to function as a negative growth regulator of prostate cancer (PCa) cells in part through its dephosphorylation of ErbB-2. cPAcP functions as a neutral protein tyrosine phosphatase (PTP) in prostate cancer cells and dephosphorylates HER-2/ErbB-2/Neu (HER-2: human epidermal growth factor receptor-2) at the phosphotyrosine (p-Tyr) residues. Injection of the secretory isoform of PAP has potent antinociceptive effects in mouse models of chronic pain. This enzyme exhibits ecto-5'-nucleotidase activity, is widely distributed, and implicated in the formation of chronic pain. Additionally, PAP could be a target molecule in specific immunotherapy for patients with nonprostate adenocarcinomas including colon and gastric cancers.
Synonym: Prostatic Acid Phosphatase, PAP, 5'-Nucleotidase, 5'-NT, Ecto-5'-Nucleotidase, Thiamine Monophosphatase, TMPase, ACPP,ACP-3,ACP3
- 分子量
- 42 kDa
- NCBI登录号
- NP_001127666
- 途径
- Synaptic Membrane, Ribonucleoside Biosynthetic Process
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