Fc epsilon RI/FCER1A (FCER1A)
(Fc Fragment of IgE Receptor Ia (FCER1A))
蛋白类型
Recombinant
宿主
Cynomolgus
资源
HEK-293 Cells
标记
This Fc epsilon RI/FCER1A protein is labelled with Fc Tag.
原理
Cynomolgus Fc epsilon RI alpha Protein, Fc Tag (BLI verified)
序列
Val 29 - Lys 204
产品特性
Cynomolgus Fc epsilon RI alpha, Fc Tag (FCA-C5255) is expressed from human 293 cells (HEK293). It contains AA Val 29 - Lys 204 (Accession # A0A7N9DA09-1).
SPR verified
FCER1A
宿主: Cynomolgus
宿主: HEK-293 Cells
Recombinant
>90 % as determined by SDS-PAGE.
应用备注
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 46.9 kDa. The protein migrates as 60-70 kDa under reducing (R) condition due to glycosylation.
限制
仅限研究用
状态
Lyophilized
缓冲液
50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH 7.5
储存条件
-20 °C
储存方法
-20°C
抗原
Fc epsilon RI/FCER1A (FCER1A)
(Fc Fragment of IgE Receptor Ia (FCER1A))
FCER1A Protein, FCE1A Protein, FcERI Protein, Iger01 Protein, RATIGER01 Protein, Fce1a Protein, Fcr-5 Protein, fcepsilonri Protein, Fc fragment of IgE receptor Ia Protein, Fc receptor, IgE, high affinity I, alpha polypeptide Protein, FCER1A Protein, Fcer1a Protein
背景
Synonyms: FCER1A,FCE1A,FcERI, Description: High affinity immunoglobulin epsilon receptor subunit alpha (FCER1A) is also known as Fc-epsilon RI-alpha (FcERI), IgE Fc receptor subunit alpha, FCE1A. FCER1A contains two Ig-like (immunoglobulin-like) domains. FCER1A binds to the Fc region of immunoglobulins epsilon and is a high affinity receptor. FCER1A is responsible for initiating the allergic response, which binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines. FCER1A plays a central role in allergic disease, coupling allergen and mast cell to initiate the inflammatory and immediate hypersensitivity responses that are characteristic of disorders such as hay fever and asthma.