CXCR4 Protein-VLP
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- 抗原 See all CXCR4 蛋白
- CXCR4 (Chemokine (C-X-C Motif) Receptor 4 (CXCR4))
- 蛋白类型
- VLP
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宿主
- 人
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资源
- HEK-293 Cells
- 原理
- Human CXCR4 / CD184 Full Length Protein-VLP (HEK293)
- 序列
- Met 1 - Ser 352
- 产品特性
- Human CXCR4 Full Length Protein-VLP (CX4-H5219) is expressed from human 293 cells (HEK293). It contains AA Met 1 - Ser 352 (Accession # P61073-1).
- 内毒素水平
- Less than 1.0 EU per μg by the LAL method.
- Top Product
- Discover our top product CXCR4 蛋白
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Chemokine (C-X-C Motif) Receptor 4 (CXCR4) protein
CXCR4 宿主: 人 宿主: HEK-293 Cells Synthetic Nanodisc
Chemokine (C-X-C Motif) Receptor 4 (CXCR4) (AA 1-80) protein (His-IF2DI Tag)CXCR4 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Chemokine (C-X-C Motif) Receptor 4 (CXCR4) (AA 1-352) protein (GST tag)CXCR4 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Chemokine (C-X-C Motif) Receptor 4 (CXCR4) (AA 1-46) protein (GST tag)CXCR4 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Chemokine (C-X-C Motif) Receptor 4 (CXCR4) (AA 1-38) protein (Fc Tag)CXCR4 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
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- 应用备注
- The protein has a calculated MW of 41.6 kDa.
- 说明
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Virus-like particles (VLPs) are formed by self-assembly of envelop/capsid proteins from viruses. Membrance Proteins can be constituted in-situ with VLPs produced from HEK293 cell cultures. These VLPs concentrate conformationally intact membrane proteins directly on the cell surface and produce soluble, high-concentration proteins perfect for immunization and antibody screening.
The VLPs provide the display of properly folded membrane proteins in their native cellular membrane in a compact size of 100~300 nm diameter (similar to the size of most viruses) making it optimal targets for dendritic cells in vivo and surface attachment for phage display. - 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- PBS, pH 7.4
- 储存条件
- -80 °C
- 储存方法
- -70°C
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- 抗原
- CXCR4 (Chemokine (C-X-C Motif) Receptor 4 (CXCR4))
- 别名
- CXCR4 / CD184 (CXCR4 产品)
- 背景
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Synonyms: CXCR4,CD184,Fusin,D2S201E,FB22,HM89,HSY3RR,LAP3,LCR1,LESTR,NPY3R,NPYR,NPYRL,NPYY3R,WHIM,
Description: C-X-C chemokine receptor type 4 is also known as fusin or CD184 (cluster of differentiation 184), CXCR4, CD184, D2S201E, FB22, HM89, HSY3RR, LAP3, LCR1, LESTR, NPY3R, NPYR, NPYRL, NPYY3R or WHIM. CXCR-4 is an alpha-chemokine receptor specific for stromal-derived-factor-1 (SDF-1 also called CXCL12), a molecule endowed with potent chemotactic activity for lymphocytes. This receptor is one of several chemokine receptors that HIV isolates can use to infect CD4+ T cells. HIV isolates that use CXCR4 are traditionally known as T-cell tropic isolates. Typically, these viruses are found late in infection. It is unclear as to whether the emergence of CXCR4 using HIV is a consequence or a cause of immunodeficiency.CXCR4 is upregulated during the implantation window in natural and hormone replacement therapy cycles in the endometrium, producing, in presence of a human blastocyst, a surface polarization of the CXCR4 receptors suggesting that this receptor is implicated in the adhesion phase of human implantation. SDF-1 and CXCR4 were believed to be a relatively "monogamous" ligand-receptor pair (other chemokines tend to use several different chemokine receptors in a fairly "promiscuous" manner). Recent evidence demonstrates ubiquitin is also a natural ligand of CXCR4. Chronic exposure to THC increased T lymphocyte CXCR4 expression on both CD4+ and CD8+ T lymphocytes. Drugs that block the CXCR4 receptor appear to be capable of "mobilizing" hematopoietic stem cells into the bloodstream as peripheral blood stem cells. - 分子量
- 41.6 kDa
- NCBI登录号
- NP_003458
- 途径
- Regulation of Cell Size, CXCR4-mediated Signaling Events
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