IL-11 Protein (AA 22-199) (His tag)
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- 抗原 See all IL-11 (IL11) 蛋白
- IL-11 (IL11) (Interleukin 11 (IL11))
- 蛋白类型
- Recombinant
- 生物活性
- Active
- 产品特性
- AA 22-199
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This IL-11 protein is labelled with His tag.
- 原理
- Human IL-11 Protein, His Tag
- 纯度
- >90 % as determined by SDS-PAGE.
- 内毒素水平
- Less than 1.0 EU per μg by the LAL method.
- Top Product
- Discover our top product IL11 蛋白
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
- PBS, pH 7.4
- 储存条件
- -20 °C
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- 抗原
- IL-11 (IL11) (Interleukin 11 (IL11))
- 别名
- IL-11 (IL11 产品)
- 别名
- IL11 Protein, AGIF Protein, IL-11 Protein, Il-11 Protein, interleukin 11 Protein, IL11 Protein, Il11 Protein
- 背景
- Interleukin-11 (IL-11) is a pleiotropic cytokine that stimulates megakaryocytopoiesis, resulting in increased production of platelets, as well as activating osteoclasts, inhibiting epithelial cell proliferation and apoptosis, and inhibiting macrophage mediator production. These functions may be particularly important in mediating the hematopoietic, osseous and mucosal protective effects of IL-11. The cytokine also possesses anti-inflammatory activity, and has been proposed as a therapeutic agent in the treatment of chronic inflammatory diseases, such as Crohn's disease and rheumatoid arthritis. Although IL-11 was initially believed to be restricted to mammals, subsequent studies demonstrated it to be expressed in fish. Despite close similarity in gene structure and conservation of key amino acids between fish and mammalian IL-11, they share relatively low overall amino acid identity and may not necessarily be functionally analogous.
- 分子量
- 21.0 kDa
- NCBI登录号
- NP_000632
- 途径
- JAK/STAT Signaling, Negative Regulation of Hormone Secretion
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