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Ret Proto-Oncogene Protein (RET) (Fc Tag)

This Recombinant Ret Proto-Oncogene protein is expressed in HEK-293 Cells.
产品编号 ABIN6964355
发货至: 中国

Quick Overview for Ret Proto-Oncogene Protein (RET) (Fc Tag) (ABIN6964355)

抗原

See all Ret Proto-Oncogene (RET) 蛋白
Ret Proto-Oncogene (RET)

蛋白类型

Recombinant

宿主

  • 8
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资源

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HEK-293 Cells
  • 标记

    This Ret Proto-Oncogene protein is labelled with Fc Tag.

    序列

    RET (Leu29-Arg635)+hFc(GLU99-ALA330)

    产品特性

    Tagged Protein: C-Human Fc tag

    纯化方法

    affinity purification
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  • 应用备注

    Optimal working dilution should be determined by the investigator.

    限制

    仅限研究用
  • 状态

    Lyophilized

    溶解方式

    Reconstitute with deionized water

    缓冲液

    Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

    储存液

    Without preservative

    储存条件

    -80 °C

    储存方法

    Store at -80°C for 12 months (Avoid repeated freezing and thawing)

    有效期

    12 months
  • 抗原

    Ret Proto-Oncogene (RET)

    别名

    RET

    背景

    Synonymes: CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET-ELE1
    Description: This gene encodes a transmembrane receptor and member of the tyrosine protein kinase family of proteins. Binding of ligands such as GDNF (glial cell-line derived neurotrophic factor) and other related proteins to the encoded receptor stimulates receptor dimerization and activation of downstream signaling pathways that play a role in cell differentiation, growth, migration and survival. The encoded receptor is important in development of the nervous system, and the development of organs and tissues derived from the neural crest. This proto-oncogene can undergo oncogenic activation through both cytogenetic rearrangement and activating point mutations. Mutations in this gene are associated with Hirschsprung disease and central hypoventilation syndrome and have been identified in patients with renal agenesis. [provided by RefSeq, Sep 2017]

    分子量

    92.29 kDa

    UniProt

    P07949

    途径

    RTK signaling, Dopaminergic Neurogenesis, Regulation of Cell Size, Tube Formation
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