tau Protein (full length, Pro301Ser-Mutant)
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- 抗原 See all tau 蛋白
- tau (tau Protein)
- 蛋白类型
- Recombinant
- 生物活性
- Active
- 产品特性
- Pro301Ser-Mutant, full length
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宿主
- 人
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资源
- 大肠杆菌（E. Coli）
- 应用范围
- SDS-PAGE (SDS), Western Blotting (WB), In vitro Assay (in vitro), In vivo Studies (in vivo)
- 原理
- Active Human Recombinant Tau441 (2N4R), P301S mutant Protein Pre-formed Fibrils
- 序列
- MAEPRQEFEV MEDHAGTYGL GDRKDQGGYT MHQDQEGDTD AGLKESPLQT PTEDGSEEPG SETSDAKSTP TAEDVTAPLV DEGAPGKQAA AQPHTEIPEG TTAEEAGIGD TPSLEDEAAG HVTQARMVSK SKDGTGSDDK KAKGADGKTK IATPRGAAPP GQKGQANATR IPAKTPPAPK TPPSSGEPPK SGDRSGYSSP GSPGTPGSRS RTPSLPTPPT REPKKVAVVR TPPKSPSSAK SRLQTAPVPM PDLKNVKSKI GSTENLKHQP GGGKVQIINK KLDLSNVQSK CGSKDNIKHV SGGGSVQIVY KPVDLSKVTS KCGSLGNIHH KPGGGQVEVK SEKLDFKDRV QSKIGSLDNI THVPGGGNKK IETHKLTFRE NAKAKTDHGA EIVYKSPVVS GDTSPRHLSN VSSTGSIDMV DSPQLATLAD EVSASLAKQG L
- 特异性
- ~45.8 kDa
- 纯化方法
- Ion-exchange Purified
- Biological Activity Comment
- Thioflavin T emission curve shows increased fluorescence (correlated to tau protein fibrillation) when active tau PFFs are combined with active tau monomers.
- Top Product
- Discover our top product tau 蛋白
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tau Protein (partial), (Pro301Leu-Mutant) (Active) protein
宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant SDS, WB, in vitro, in vivo Active
tau Protein (AA 241-380) protein (His tag)宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
tau Protein (AA 1-383) protein (His tag)宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 90 % by SDS - PAGE SDS
tau Protein (AA 200-380) protein (His tag)宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
tau Protein (AA 1-352) protein (His tag)宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 85 % by SDS - PAGE SDS
tau Protein (AA 1-381) protein (His tag)宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 85 % by SDS - PAGE SDS
tau Protein (AA 1-412) protein (His tag)宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 80 % by SDS - PAGE SDS
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 浓度
- Lot specific
- 缓冲液
- 10 mM HEPES, 100 mM NaCl pH 7.4
- 储存条件
- -80 °C
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- 抗原
- tau (tau Protein)
- 别名
- Tau (tau 产品)
- 别名
- DDPAC Protein, FTDP-17 Protein, MAPTL Protein, MSTD Protein, MTBT1 Protein, MTBT2 Protein, PPND Protein, TAU Protein, tau Protein, PHF-tau Protein, microtubule associated protein tau Protein, MAPT Protein
- 背景
- Alzheimer's Disease (AD) is the most common neurodegenerative disease, affecting 10 % of seniors over the age of 65 (1). It was named after Alois Alzheimer, a German scientist who discovered tangled bundles of fibrils where neurons had once been in the brain of a deceased patient in 1907 (2). Tau (tubulin-associated unit) is normally located in the axons of neurons where it stabilizes microtubules. Tauopathies such as AD are characterized by neurofibrillary tangles containing hyperphosphorylated tau fibrils (3). There are six isoforms of tau in the adult human brain: three with four repeat units (4R) and three with three repeat units (3R) (4). 2N4R, or Tau-441 is the full length tau protein. P301S is a mutation encoded by exon 10 (4) that impairs the ability of tau to assemble microtubules (5).
- NCBI登录号
- NP_005901
- UniProt
- P10636
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