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SIRT2 Protein (GST tag)

Rockland 009-001-t32s SIRT2 宿主: 人 宿主: 大肠杆菌(E. Coli) Recombinant >85% WB
Rockland
产品编号 ABIN6700529
Supplier Product No.: 009-001-t32s
发货至: 中国
  • 抗原 See all SIRT2 蛋白
    SIRT2 (Sirtuin 2 (SIRT2))
    蛋白类型
    Recombinant
    宿主
    • 6
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    资源
    • 7
    • 4
    • 1
    大肠杆菌(E. Coli)
    标记
    This SIRT2 protein is labelled with GST tag.
    应用范围
    Western Blotting (WB)
    Supplier Product No.
    009-001-t32s
    Supplier
    Rockland
    原理
    SIRT2 recombinant protein-GST fusion protein
    纯化方法
    Full-length recombinant human SIRT2 was expressed in E. coli cells using an N-Terminal Glutathione-S-Transferase fusion protein. The purity was determined to be >85% by densitometry.
    纯度
    >85%
    Top Product
    Discover our top product SIRT2 蛋白
  • 应用备注

    Western_Blot_Dilution: User Optimized

    Application_Note: SIRT2 Protein is suitable for use in Western Blot. Expect a band approximately ~64 kDa on specific lysates or tissues. Specific conditions for reactivity should be optimized by the end user.

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    0.2 μg/μL
    缓冲液
    SIRT2 Protein is stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25 % glycerol.
    储存条件
    -80 °C
    储存方法
    Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
    有效期
    12 months
  • 抗原
    SIRT2 (Sirtuin 2 (SIRT2))
    别名
    SIRT2 (SIRT2 产品)
    背景

    Synonyms: Regulatory protein SIR2 homolog 2, SIR2-like protein 2, SIRT2, SIR2L, SIR2L2, Sirtuin 2

    Background: SIRT2 is a member of the sirtuin family of proteins which are homologs to the yeast Sir2 protein. Sirtuin family contain a sirtuin core domain and are grouped into four classes with SIRT2 being a member of class I. Inhibition of SIRT2 can lead to neuroprotection in cellular and invertebrate models of Huntington's disease (1). Huntington's disease is characterized by increased sterols synthesis in neuronal cells and this process is reversed by SIRT2 inhibition. SIRT2 can deacetylate lys40 of alpha-tubulin both in vitro and in vivo (2). Knockdown of SIRT2 via small interfering RNA results in tubulin hyperacetylation. SIRT2 Protein is ideal for investigators involved in Signaling Proteins, Deacetylase/Demethylase Proteins, Cancer, Cell Cycle, and Inflammation research.

    NCBI登录号
    NM_030593
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