Complexin1 belongs to a family of SNARE complex binding proteins that were suggested to be either facilitators or inhibitors of vesicle exocytosis. Complexin 1 exhibits reduced Ca2+-triggered fast neurotransmitter release at hippocampal glutamatergic synapses, indicating that this protein is a positive regulator of transmitter release. In contrast, it inhibits SNARE-mediated liposome and cell fusions in vitro, which lead to the hypothesis that it acts as fusion clamps of synaptic exocytosis. Recombinant Complexin 1 protein was expressed in E.coli and purified by using conventional chromatography techniques. Synonyms: CPXL1, CPX1, Synaphin-2, Complexin 1, Complexin I, CPX1, Synaphin 2,. NCBI no.: NP_006642
分子量
17.1 kDa (154 aa), confirmed by MALDI-TOF. (Molecular weight on SDS-PAGE will appear higher)