MDIG Protein, MINA53 Protein, NO52 Protein, ROX Protein, 1810047J07Rik Protein, 2410057H13Rik Protein, 3830408E23Rik Protein, AI449204 Protein, Mina53 Protein, mina Protein, MGC83527 Protein, MINA Protein, DKFZp459K0725 Protein, Mina Protein, ribosomal oxygenase 2 Protein, MYC induced nuclear antigen Protein, ribosomal oxygenase 2 L homeolog Protein, RIOX2 Protein, Riox2 Protein, MINA Protein, riox2.L Protein, riox2 Protein
背景
MINA is an oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. This protein is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. It also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39'. MINA may play an important role in cell growth and survival. It may be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles. Recombinant human MINA protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.