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IL-15 Protein (AA 49-162)

IL15 宿主: 人 宿主: 大肠杆菌(E. Coli) Recombinant >95 % as determined by SDS-PAGE. Active
产品编号 ABIN6386427
发货至: 中国
  • 抗原 See all IL-15 (IL15) 蛋白
    IL-15 (IL15) (Interleukin 15 (IL15))
    蛋白类型
    Recombinant
    生物活性
    Active
    产品特性
    AA 49-162
    宿主
    • 21
    • 7
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    资源
    • 33
    • 10
    • 10
    • 2
    • 2
    大肠杆菌(E. Coli)
    序列
    AA 49-162
    纯度
    >95 % as determined by SDS-PAGE.
    内毒素水平
    Less than 0.1 EU per μg by the LAL method.
    Top Product
    Discover our top product IL15 蛋白
  • 限制
    仅限研究用
  • 状态
    Lyophilized
    缓冲液
    PBS, pH 7.4
    注意事项
    Please avoid repeated freeze-thaw cycles.
    储存条件
    -20 °C
  • 抗原
    IL-15 (IL15) (Interleukin 15 (IL15))
    别名
    IL-15 (IL15 产品)
    别名
    IL15 Protein, AI503618 Protein, IL-15 Protein, interleukin 15 Protein, IL15 Protein, Il15 Protein
    背景
    Interleukin 15 is also known as IL15, IL-15, and is a cytokine with structural similarity to IL-2. Like IL-2, IL-15 binds to and signals through the IL-2/IL-15 beta chain (CD122) and the common gamma chain (gamma-C, CD132). IL-15 is secreted by mononuclear phagocytes (and some other cells) following infection by virus(es). This cytokine induces cell proliferation of natural killer cells, cells of the innate immune system whose principal role is to kill virally infected cells. Interleukin 15 (IL-15) regulates T and natural killer (NK) cell activation and proliferation. Survival signals that maintain memory T cells in the absence of antigen are provided by IL-15. This cytokine is also implicated in NK cell development. In rodent lymphocytes, IL-15 prevents apoptosis by inducing an apoptosis inhibitor, BCL2L1/BCL-x(L). IL-15 has been shown to enhance the anti-tumor immunity of CD8+ T cells in pre-clinical models. A phase I clinical trial to evaluate the safety, dosing, and anti-tumor efficacy of IL-15 in patients with metastatic melanoma and renal cell carcinoma (kidney cancer) has begun to enroll patients at the National Institutes of Health.
    分子量
    12.8 kDa
    途径
    JAK/STAT Signaling, Glycosaminoglycan Metabolic Process
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