HAVCR1 Protein (AA 21-295) (Fc Tag)
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- 抗原 See all HAVCR1 蛋白
- HAVCR1 (Hepatitis A Virus Cellular Receptor 1 (HAVCR1))
- 蛋白类型
- Recombinant
- 产品特性
- AA 21-295
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This HAVCR1 protein is labelled with Fc Tag.
- 原理
- Tim-1 (human):Fc (mouse) (rec.)
- 特异性
- The extracellular domain of human Tim-1 (aa 21-295) is fused to the N-terminus of the Fc region of mouse IgG2a.
- 产品特性
- Protein. The extracellular domain of human Tim-1 (aa 21-295) is fused to the N-terminus of the Fc region of mouse IgG2a. Source: HEK 293 cells. Endotoxin content: <5EU/mg protein (LAL test, Lonza). Lyophilized from 0.2μm-filtered solution in PBS. Purity: >98 % (SDS-PAGE). The TIM (T cell/transmembrane, immunoglobulin and mucin) family plays a critical role in regulating immune responses, including allergy, asthma, transplant tolerance, autoimmunity and the response to viral infections. The unique structure of TIM immunoglobulin variable region domains allows highly specific recognition of phosphatidylserine (PtdSer), exposed on the surface of apoptotic cells. TIM-1 (T cell-immunoglobulinmucin, also KIM-1 and HAVcr-1) is a 100 kDa, type I transmembrane glycoprotein member of the TIM family of immunoglobulin superfamily molecules. There are two cytoplasmic alternate splice forms of TIM1. One is a long (359 aa) kidney form termed TIM-1b, and one is a short (334 aa) liver form termed TIM-1a. TIM-1, important for asthma and allergy, is preferentially expressed on T-helper 2 (Th2) cells and functions as a potent costimulatory molecule for T cell activation.
- 纯度
- >98 % (SDS-PAGE)
- 内毒素水平
- <5EU/mg protein (LAL test, Lonza).
- Biological Activity Comment
- Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated human T cells.
- Top Product
- Discover our top product HAVCR1 蛋白
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 浓度
- Lot specific
- 缓冲液
- Lyophilized from 0.2μm-filtered solution in PBS.
- 注意事项
- Avoid freeze/thaw cycles.
- 储存条件
- 4 °C,-20 °C
- 储存方法
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Short Term Storage: +4°C
Long Term Storage: -20°C
Use & Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
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- 抗原
- HAVCR1 (Hepatitis A Virus Cellular Receptor 1 (HAVCR1))
- 别名
- Tim-1 (HAVCR1 产品)
- 别名
- HAVCR Protein, HAVCR-1 Protein, KIM-1 Protein, KIM1 Protein, TIM Protein, TIM-1 Protein, TIM1 Protein, TIMD-1 Protein, TIMD1 Protein, Kim1 Protein, HAVCR1 Protein, LOC100226241 Protein, AI503787 Protein, Tim1 Protein, Timd1 Protein, hepatitis A virus cellular receptor 1 Protein, hepatitis A virus cellular receptor 1 homolog Protein, HAVCR1 Protein, Havcr1 Protein, LOC100226241 Protein
- 物质类
- Virus
- 背景
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Alternate Names/Synonyms: TIM1, KIM1, TIMD1, Hepatitis A Virus Cellular Receptor 1, HAVcr-1, T Cell Immunoglobulin and Mucin Domain-containing Protein 1, T Cell Membrane Protein 1
Product Description: The TIM (T cell/transmembrane, immunoglobulin and mucin) family plays a critical role in regulating immune responses, including allergy, asthma, transplant tolerance, autoimmunity and the response to viral infections. The unique structure of TIM immunoglobulin variable region domains allows highly specific recognition of phosphatidylserine (PtdSer), exposed on the surface of apoptotic cells. TIM-1 (T cell-immunoglobulinmucin, also KIM-1 and HAVcr-1) is a 100 kDa, type I transmembrane glycoprotein member of the TIM family of immunoglobulin superfamily molecules. There are two cytoplasmic alternate splice forms of TIM1. One is a long (359 aa) kidney form termed TIM-1b, and one is a short (334 aa) liver form termed TIM-1a. TIM-1, important for asthma and allergy, is preferentially expressed on T-helper 2 (Th2) cells and functions as a potent costimulatory molecule for T cell activation.
- 分子量
- ~110kDa (SDS-PAGE)
- NCBI登录号
- NP_036338
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