CCL4 Protein (AA 24-92) (Fc Tag)
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- 抗原 See all CCL4 蛋白
- CCL4 (Chemokine (C-C Motif) Ligand 4 (CCL4))
- 蛋白类型
- Recombinant
- 产品特性
- AA 24-92
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宿主
- 人
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资源
- CHO Cells
- 标记
- This CCL4 protein is labelled with Fc Tag.
- 原理
- CCL4 (human):Fc (human) (rec.)
- 特异性
- The extracellular domain of human CCL4 (aa 24-92) is fused to the N-terminus of the Fc region of human IgG1.
- 产品特性
- Protein. The extracellular domain of human CCL4 (aa 24-92) is fused to the N-terminus of the Fc region of human IgG1. Source: CHO cells. Endotoxin content: <0.06EU/μg protein (LAL test, Lonza). Lyophilized from 0.2μm-filtered solution in PBS. Purity: >98 % (SDS-PAGE). CCL4, (C-C motif chemokine 4, macrophage inflammatory protein 1beta) is a chemokine secreted at sites of inflammation by activated leukocytes, lymphocytes, vascular endothelial cells and pulmonary smooth cells. CCL4 attracts a variety of immune cells to sites of microbial infection as well as to pathologic inflammation, such as allergic asthma and ischemic myocardium. Full-length and truncated CCL4 exert biological activity through the receptor CCR5. The truncated form of CCL4 interacts additionally with CCR1 and CCR2b. The ability of CCL4 to bind CCR5 inhibits the cellular entry of M-tropic HIV. Both CCL4 forms block HIV-1 infection of T cells by inducing the downregulation of CCR5.
- 纯度
- >98 % (SDS-PAGE)
- 内毒素水平
- <0.06EU/μg protein (LAL test, Lonza).
- Top Product
- Discover our top product CCL4 蛋白
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Chemokine (C-C Motif) Ligand 4 (CCL4) (AA 24-92) (Active) protein
CCL4 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant CMA Active
Chemokine (C-C Motif) Ligand 4 (CCL4) (AA 24-92) (Active) protein (Biotin)CCL4 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 97 % by SDS PAGE CMA Active
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 浓度
- Lot specific
- 缓冲液
- Lyophilized from 0.2μm-filtered solution in PBS.
- 注意事项
- Avoid freeze/thaw cycles.
- 储存条件
- 4 °C,-20 °C
- 储存方法
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Short Term Storage: +4°C
Long Term Storage: -20°C
Use & Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
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- 抗原
- CCL4 (Chemokine (C-C Motif) Ligand 4 (CCL4))
- 别名
- CCL4 (CCL4 产品)
- 背景
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Alternate Names/Synonyms: C-C Motif Chemokine 4, Lymphocyte Activation Gene 1 Protein, LAG-1, Macrophage Inflammatory Protein 1beta, MIP-1beta, T Cell Activation Protein 2, ACT-2, Small-inducible Cytokine A4, PAT 744, Protein H400
Product Description: CCL4, (C-C motif chemokine 4, macrophage inflammatory protein 1beta) is a chemokine secreted at sites of inflammation by activated leukocytes, lymphocytes, vascular endothelial cells and pulmonary smooth cells. CCL4 attracts a variety of immune cells to sites of microbial infection as well as to pathologic inflammation, such as allergic asthma and ischemic myocardium. Full-length and truncated CCL4 exert biological activity through the receptor CCR5. The truncated form of CCL4 interacts additionally with CCR1 and CCR2b. The ability of CCL4 to bind CCR5 inhibits the cellular entry of M-tropic HIV. Both CCL4 forms block HIV-1 infection of T cells by inducing the downregulation of CCR5.
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