IL23 Protein (AA 20-189, AA 23-328) (DYKDDDDK Tag)
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- 抗原 See all IL23 蛋白
- IL23 (Interleukin 23 (IL23))
- 蛋白类型
- Recombinant
- 产品特性
- AA 20-189, AA 23-328
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This IL23 protein is labelled with DYKDDDDK Tag.
- 原理
- IL-23 (human) (rec.)
- 特异性
- Human IL-12p40 peptide (aa 23-328) is fused at the C-terminus to a 18 aa linker peptide (GSTSGSGKPGSGEGSTKG) and to the IL-23p19 peptide (aa 20-189) and fused at the N-terminus to a FLAG®-tag.
- 产品特性
- Protein. Human IL-12p40 peptide (aa 23-328) is fused at the C-terminus to a 18 aa linker peptide (GSTSGSGKPGSGEGSTKG) and to the IL-23p19 peptide (aa 20-189) and fused at the N-terminus to a FLAG®-tag. Source: HEK 293 cells. Endotoxin content: <0.06EU/μg purified protein (LAL test, Lonza). Lyophilized from 0.2μm-filtered solution in PBS. Purity: >90 % (SDS-PAGE). Interleukin-23 (IL-23) is a heterodimeric cytokine and a member of the IL-12 family involved in innate and adaptive immunity. It is composed of the IL-12 p40 chain covalently linked to p19, a chain related to the IL-12 p35 subunit. IL-23 signals through the IL-23 receptor complex, which is composed of the IL-12Rbeta1 chain and a gp130-like chain, IL-23R. Triggering of the IL-23 receptor complex leads to the activation of Tyk2, Jak2 and STAT1, 3 and 4. IL-23 induces IFN-gamma production, Th1 cell differentiation, and activation of the antigen-presenting functions of dendritic cells. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and important for tumorigenesis.
- 纯度
- >90 % (SDS-PAGE)
- 内毒素水平
- <0.06EU/μg purified protein (LAL test, Lonza).
- Top Product
- Discover our top product IL23 蛋白
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Interleukin 23 (IL23) protein
IL23 宿主: 小鼠 宿主: Baculovirus infected Insect Cells Recombinant >95 % as determined by reducing SDS-PAGE.
Interleukin 23 (IL23) proteinIL23 宿主: 小鼠 宿主: 人细胞 Recombinant > 95 % as determined by SDS-PAGE
Interleukin 23 (IL23) protein (His tag)IL23 宿主: 小鼠 宿主: 人细胞 Recombinant > 95 % as determined by reducing SDS-PAGE.
Interleukin 23 (IL23) protein (Fc Tag)IL23 宿主: 人 宿主: 人细胞 Recombinant >95 % as determined by reducing SDS-PAGE.
Interleukin 23 (IL23) (Active) protein (His tag)IL23 宿主: 人 宿主: HEK-293 Cells Recombinant > 90 % as determined by reducing SDS-PAGE. Active
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 浓度
- Lot specific
- 缓冲液
- Lyophilized from 0.2μm-filtered solution in PBS.
- 注意事项
- After opening, prepare aliquots and store at -20 °C. Avoid freeze/thaw cycles. PBS containing at least 0.1 % BSA should be used for further dilutions.
- 储存条件
- 4 °C,-20 °C
- 储存方法
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Short Term Storage: +4°C
Long Term Storage: -20°C
Use & Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
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- 抗原
- IL23 (Interleukin 23 (IL23))
- 别名
- IL-23 (IL23 产品)
- 别名
- IL-23 Protein, p19 Protein, SGRF Protein, il23p19 Protein, interleukin 23, alpha subunit p19 Protein, interleukin 23 subunit alpha Protein, Il23a Protein, IL23A Protein
- 背景
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Alternate Names/Synonyms: Interleukin-23
Product Description: Interleukin-23 (IL-23) is a heterodimeric cytokine and a member of the IL-12 family involved in innate and adaptive immunity. It is composed of the IL-12 p40 chain covalently linked to p19, a chain related to the IL-12 p35 subunit. IL-23 signals through the IL-23 receptor complex, which is composed of the IL-12Rbeta1 chain and a gp130-like chain, IL-23R. Triggering of the IL-23 receptor complex leads to the activation of Tyk2, Jak2 and STAT1, 3 and 4. IL-23 induces IFN-gamma production, Th1 cell differentiation, and activation of the antigen-presenting functions of dendritic cells. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and important for tumorigenesis.
- 分子量
- ~70kDa (SDS-PAGE)
- UniProt
- Q9NPF7, P29460
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