Optimal working dilution should be determined by the investigator.
限制
仅限研究用
状态
Liquid
浓度
0.1-2 mg/mL
缓冲液
20 mM Tris-HCl based buffer, pH 8.0
储存条件
-80 °C,4 °C,-20 °C
储存方法
Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
MAP2A Protein, MAP2B Protein, MAP2C Protein, MAP2R Protein, Mtap2 Protein, MAP-2 Protein, Mtap-2 Protein, xmap2 Protein, MGC53131 Protein, a730034c02 Protein, zgc:103474 Protein, zgc:113974 Protein, microtubule associated protein 2 Protein, microtubule-associated protein 2 Protein, microtubule associated protein 2 S homeolog Protein, MAP2 Protein, Map2 Protein, map2.S Protein, map2 Protein
背景
Cotranslationally roves the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). The catalytic activity of human METAP2 toward Met-Val peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is responsible for processing proteins containing N-terminal Met-Val and Met-Thr sequences in vivo.Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis.