ABL1 Protein (AA 4-194, partial) (GST tag)
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- 抗原 See all ABL1 蛋白
- ABL1 (C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1))
- 蛋白类型
- Recombinant
- 产品特性
- AA 4-194, partial
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宿主
- 小鼠
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资源
- 大肠杆菌（E. Coli）
- 标记
- This ABL1 protein is labelled with GST tag.
- 应用范围
- SDS-PAGE (SDS)
- 序列
- ICLKLVGCKS KKGLSSSSSC YLEEALQRPV ASDFEPQGLS EAARWNSKEN LLAGPSENDP NLFVALYDFV ASGDNTLSIT KGEKLRVLGY NHNGEWCEAQ TKNGQGWVPS NYITPVNSLE KHSWYHGPVS RNAAEYLLSS GINGSFLVRE SESSPGQRSI SLRYEGRVYH YRINTASDGK LYVSSESRFN T
- 纯化方法
- SDS-PAGE
- 纯度
- > 90 %
- Top Product
- Discover our top product ABL1 蛋白
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C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1) (AA 931-1030) protein (GST tag)
ABL1 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AA, AP
C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1) (Active) protein (GST tag)ABL1 宿主: 人 宿主: Baculovirus infected Insect Cells Recombinant > 75 % as determined by reducing SDS-PAGE. Active
C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1) (AA 4-194), (partial) protein (GST tag)ABL1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant 90 % ELISA
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 0.1-2 mg/mL
- 缓冲液
- 20 mM Tris-HCl based buffer, pH 8.0
- 储存条件
- -80 °C,4 °C,-20 °C
- 储存方法
- Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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- 抗原
- ABL1 (C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1))
- 别名
- ABL1 (ABL1 产品)
- 别名
- ABL Protein, JTK7 Protein, bcr/abl Protein, c-ABL Protein, p150 Protein, v-abl Protein, AI325092 Protein, Abl Protein, E430008G22Rik Protein, c-Abl Protein, ABL proto-oncogene 1, non-receptor tyrosine kinase Protein, c-abl oncogene 1, non-receptor tyrosine kinase Protein, Tyrosine-protein kinase abl-1 Protein, ABL1 Protein, Abl1 Protein, abl-1 Protein, abl1 Protein
- 背景
- Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton rodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin rodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation), ANXA1 (involved in mbrane anchoring), DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling), or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9. Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses through MUSK, inhibits PDGFRB-mediated chotaxis and modulates the endocytosis of activated B-cell receptor complexes. Other substrates which are involved in endocytosis regulation are the caveolin (CAV1) and RIN1. Moreover, ABL1 regulates the CBL family of ubiquitin ligases that drive receptor down-regulation and actin rodeling. Phosphorylation of CBL leads to increased EGFR stability. Involved in late-stage autophagy by regulating positively the trafficking and function of lysosomal components. ABL1 targets to mitochondria in response to oxidative stress and thereby mediates mitochondrial dysfunction and cell death. ABL1 is also translocated in the nucleus where it has DNA-binding activity and is involved in DNA-damage response and apoptosis. Many substrates are known mediators of DNA repair: DDB1, DDB2, ERCC3, ERCC6, RAD9A, RAD51, RAD52 or WRN. Activates the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates TP73, a primary regulator for this type of damage-induced apoptosis. Phosphorylates the caspase CASP9 on 'Tyr-191' and regulates its processing in the apoptotic response to DNA damage. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks
- 分子量
- 48.5 kDa
- UniProt
- P00520
- 途径
- Apoptosis, Regulation of Muscle Cell Differentiation, Platelet-derived growth Factor Receptor Signaling, Lipid Metabolism
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