POLR3C
宿主: 人
宿主: HEK-293 Cells
Recombinant
> 80 % as determined by SDS-PAGE and Coomassie blue staining
AbP, STD
应用备注
Optimal working dilution should be determined by the investigator.
限制
仅限研究用
状态
Liquid
浓度
0.1-2 mg/mL
缓冲液
20 mM Tris-HCl based buffer, pH 8.0
储存条件
-80 °C,4 °C,-20 °C
储存方法
Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
抗原
POLR3C
(Polymerase (RNA) III (DNA Directed) Polypeptide C (62kD) (POLR3C))
rpc3 Protein, rpc62 Protein, 4933407E01Rik Protein, RPC3 Protein, RPC62 Protein, zgc:56348 Protein, polymerase (RNA) III (DNA directed) polypeptide C (62kD) S homeolog Protein, RNA polymerase III subunit C Protein, polymerase (RNA) III (DNA directed) polypeptide C (62kD) Protein, polymerase (RNA) III (DNA directed) polypeptide C Protein, polr3c.S Protein, POLR3C Protein, polr3c Protein, Polr3c Protein
背景
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other mbers of the subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as tplate for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway.