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Granulin Protein (GRN) (AA 1-602)

GRN 宿主: 大鼠 宿主: HEK-293 Cells Recombinant >95 % (SDS-PAGE) SDS
产品编号 ABIN5564460
发货至: 中国
  • 抗原 See all Granulin (GRN) 蛋白
    Granulin (GRN)
    蛋白类型
    Recombinant
    产品特性
    AA 1-602
    宿主
    • 13
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    大鼠
    资源
    • 8
    • 7
    • 7
    • 2
    HEK-293 Cells
    应用范围
    SDS-PAGE (SDS)
    原理
    Progranulin (rat) (rec.) (untagged)
    交叉反应
    大鼠
    产品特性
    Signal peptide and rat progranulin (aa 1-602) is untagged. Reflects the native sequence with no additional aa.
    纯度
    >95 % (SDS-PAGE)
    内毒素水平
    <0.01EU/μg purified protein (LAL test).
    Top Product
    Discover our top product GRN 蛋白
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 状态
    Lyophilized
    浓度
    Lot specific
    缓冲液
    Contains PBS.
    注意事项
    After reconstitution, prepare aliquots and store at -20 °C. Centrifuge lyophilized vial before opening and reconstitution. Do not freeze/thaw. PBS containing at least 0.1 % BSA should be used for further dilutions.
    储存条件
    4 °C,-20 °C
    储存方法

    Short Term Storage: +4°C

    Long Term Storage: -20°C

    Use & Stability: Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.

    有效期
    6 months
  • 抗原
    Granulin (GRN)
    别名
    Progranulin (GRN 产品)
    背景

    Proepithelin, PEPI, PC Cell-derived Growth Factor

    Progranulin (PGRN) is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of frontotemporal degeneration (FTLD). In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimer's Disease (AD) and potentially for MCI (Mild Cognitive Impairment). Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis.

    分子量
    ~73kDa (SDS-PAGE)
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