Granulin Protein (GRN) (AA 1-589)
-
- 抗原 See all Granulin (GRN) 蛋白
- Granulin (GRN)
- 蛋白类型
- Recombinant
- 产品特性
- AA 1-589
-
宿主
- 小鼠
-
资源
- HEK-293 Cells
- 应用范围
- SDS-PAGE (SDS)
- 原理
- Progranulin (mouse) (rec.) (untagged)
- 交叉反应
- 小鼠
- 产品特性
- Signal peptide and mouse progranulin (aa 1-589) is untagged. Reflects the native sequence with no additional aa.
- 纯度
- >95 % (SDS-PAGE)
- 内毒素水平
- <0.01EU/μg purified protein (LAL test).
- Top Product
- Discover our top product GRN 蛋白
-
Granulin (GRN) (AA 494-593) protein (GST tag)
GRN 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Granulin (GRN) (AA 364-430) protein (His tag)GRN 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Granulin (GRN) (AA 289-426) protein (His-IF2DI Tag)GRN 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Granulin (GRN) (AA 1-593) protein (GST tag)GRN 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Granulin (GRN) protein (His tag)GRN 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 90 % as determined by SDS-PAGE
-
- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
-
- 状态
- Lyophilized
- 浓度
- Lot specific
- 缓冲液
- Contains PBS.
- 注意事项
- After reconstitution, prepare aliquots and store at -20 °C. Avoid freeze/thaw cycles. Centrifuge lyophilized vial before opening and reconstitution. PBS containing at least 0.1 % BSA should be used for further dilutions.
- 储存条件
- 4 °C,-20 °C
- 储存方法
-
Short Term Storage: +4°C
Long Term Storage: -20°C
Use & Stability: Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
- 有效期
- 6 months
-
- 抗原
- Granulin (GRN)
- 别名
- Progranulin (GRN 产品)
- 背景
-
Proepithelin, PEPI, PC Cell-derived Growth Factor
Progranulin (PGRN) is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of frontotemporal degeneration (FTLD). In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimer's Disease (AD) and potentially for MCI (Mild Cognitive Impairment). Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis. EphA2, a member of the large family of Ephrin receptor tyrosine kinases, is also a functional signaling receptor for progranulin as reported recently.
- 分子量
- ~70kDa (SDS-PAGE)
- UniProt
- P28798
-
