Granulin Protein (GRN) (AA 1-593)
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- 抗原 See all Granulin (GRN) 蛋白
- Granulin (GRN)
- 蛋白类型
- Recombinant
- 生物活性
- Active
- 产品特性
- AA 1-593
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宿主
- 人
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资源
- HEK-293 Cells
- 应用范围
- SDS-PAGE (SDS)
- 交叉反应
- 人
- 产品特性
- Signal peptide and human progranulin (aa 1-593) is untagged. Reflects the native sequence with no additional aa.
- 纯度
- >98 % (SDS-PAGE)
- 内毒素水平
- <0.01EU/μg purified protein (LAL test, Lonza).
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- Discover our top product GRN 蛋白
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Granulin (GRN) (AA 494-593) protein (GST tag)
GRN 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Granulin (GRN) (AA 364-430) protein (His tag)GRN 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Granulin (GRN) (AA 289-426) protein (His-IF2DI Tag)GRN 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Granulin (GRN) (AA 1-593) protein (GST tag)GRN 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Granulin (GRN) protein (His tag)GRN 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 90 % as determined by SDS-PAGE
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 说明
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Activates phospho-ERK1/2 in neuronal mouse P19 cells. Regulates food intake and body weight (see reference 1).
- 限制
- 仅限研究用
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- 状态
- Solid
- 浓度
- Lot specific
- 缓冲液
- Lyophilized. Contains PBS.
- 储存条件
- 4 °C,-20 °C
- 储存方法
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Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. - 有效期
- 6 months
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- 抗原
- Granulin (GRN)
- 别名
- Progranulin (GRN 产品)
- 别名
- GRN Protein, grn Protein, wu:fb11g12 Protein, wu:fj18f05 Protein, MGC53354 Protein, DKFZp459H066 Protein, CLN11 Protein, GEP Protein, GP88 Protein, PCDGF Protein, PEPI Protein, PGRN Protein, epithelin Protein, acrogranin Protein, granulin precursor Protein, granulin a Protein, Granulins Protein, granulin L homeolog Protein, granulin Protein, GRN Protein, grna Protein, grn Protein, grn.L Protein, granulin Protein, ORF1 granulin Protein, Grn Protein
- 物质类
- Viral Protein
- 背景
- Progranulin (PGRN) is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of frontotemporal degeneration (FTLD). In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimer's Disease (AD) and potentially for MCI (Mild Cognitive Impairment). Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis.
- 分子量
- ~74kDa (glycosylated protein by SDS-PAGE)
- UniProt
- P28799
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