SNCA Protein (full length)
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- 抗原 See all SNCA 蛋白
- SNCA (Synuclein, alpha (SNCA))
- 蛋白类型
- Recombinant
- 生物活性
- Active
- 产品特性
- full length
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宿主
- 人
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资源
- 大肠杆菌（E. Coli）
- 应用范围
- SDS-PAGE (SDS), Western Blotting (WB), In vitro Assay (in vitro), In vivo Studies (in vivo)
- 序列
- MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVATVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGSIAA ATGFVKKDQL GKNEEGAPQE GILEDMPVDP DNEAYEMPSE EGYQDYEPEA
- 特异性
- ~14.46 kDa
- 纯化方法
- Ion-exchange Purified
- 纯度
- >95% pure using SDS-PAGE analysis.
- Biological Activity Comment
- Endogenous alpha-synuclein phosphorylation. 100 μM alpha synuclein protein monomer (SPR-321) seeded with 10 nM alpha synuclein protein PFF (SPR-322) in 25 μM Thioflavin T (PBS pH 7.4, 100 μl reaction volume) generated a fluorescence intensity of 13,000 Relative Fluorescence Units after incubation at 37°C with shaking at 600 rpm. Fluorescence was measured by excitation at 450 nm and emission at 485 nm on a Molecular Devices Gemini XPS microplate reader.
- Top Product
- Discover our top product SNCA 蛋白
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Synuclein, alpha (SNCA) (Ala53Thr-Mutant) (Active) protein
SNCA 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant SDS, WB, in vitro, in vivo Active
Synuclein, alpha (SNCA) (full length) (Active) proteinSNCA 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant SDS, WB, in vitro, in vivo Active
Synuclein, alpha (SNCA) proteinSNCA 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % as determined by SDS-PAGE
Synuclein, alpha (SNCA) (AA 1-140) protein (His tag)SNCA 宿主: 大鼠 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Synuclein, alpha (SNCA) (AA 1-140) protein (GST tag)SNCA 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Synuclein, alpha (SNCA) (AA 31-140) protein (GST tag)SNCA 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Synuclein, alpha (SNCA) (active) proteinSNCA 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % pure SDS
Synuclein, alpha (SNCA) (AA 1-139), (partial) protein (GST tag)SNCA 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant 90 % SDS, ELISA
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 说明
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Certified >95% pure using SDS-PAGE analysis.
- 限制
- 仅限研究用
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- 浓度
- Lot specific
- 缓冲液
- PBS
- 储存条件
- -80 °C
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- 抗原
- SNCA (Synuclein, alpha (SNCA))
- 别名
- Alpha Synuclein (SNCA 产品)
- 别名
- snca Protein, MGC64356 Protein, LOC619283 Protein, NACP Protein, alphaSYN Protein, PARK1 Protein, PARK4 Protein, PD1 Protein, synuclein alpha L homeolog Protein, alpha-synuclein Protein, synuclein alpha Protein, synuclein, alpha Protein, snca.L Protein, LOC619283 Protein, SNCA Protein, Snca Protein
- 背景
- Alpha-Synuclein (SNCA) is expressed predominantly in the brain, where it is concentrated in presynaptic nerve terminals (1). Alpha-synuclein is highly expressed in the mitochondria of the olfactory bulb, hippocampus, striatum and thalamus (2). Functionally, it has been shown to significantly interact with tubulin (3), and may serve as a potential microtubule-associated protein. It has also been found to be essential for normal development of the cognitive functions, inactivation may lead to impaired spatial learning and working memory (4). SNCA fibrillar aggregates represent the major non A-beta component of Alzheimers disease amyloid plaque, and a major component of Lewy body inclusions, and Parkinson's disease. Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the progressive accumulation in selected neurons of protein inclusions containing alpha-synuclein and ubiquitin (5, 6).
- 分子量
- 14.46 kDa
- 基因ID
- 6622
- NCBI登录号
- NP_000336
- UniProt
- P37840
- 途径
- Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Platelet-derived growth Factor Receptor Signaling, Negative Regulation of Transporter Activity, Regulation of long-term Neuronal Synaptic Plasticity
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