TIGIT
(T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT))
蛋白类型
Recombinant
生物活性
Active
产品特性
AA 17-138
宿主
大鼠
资源
HEK-293 Cells
标记
This TIGIT protein is labelled with Fc Tag.
应用范围
Functional Studies (Func)
序列
AA 17-138
产品特性
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 40 kDa. As a result of glycosylation, the protein migrates as 48-55 kDa under reducing (R) condition, and 85-110 kDa under non-reducing (NR) condition (SDS-PAGE).
TIGIT
宿主: Cynomolgus
宿主: Mammalian Cells
Recombinant
The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
限制
仅限研究用
状态
Lyophilized
缓冲液
Tris with Glycine, Arginine and NaCl, pH 7.5
注意事项
Please avoid repeated freeze-thaw cycles.
储存条件
-20 °C
抗原
TIGIT
(T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT))
VSIG9 Protein, VSTM3 Protein, WUCAM Protein, ENSMUSG00000071552 Protein, Vstm3 Protein, RGD1563191 Protein, T-cell immunoreceptor with Ig and ITIM domains Protein, T cell immunoreceptor with Ig and ITIM domains Protein, TIGIT Protein, Tigit Protein
背景
T-cell immunoreceptor with Ig and ITIM domains (TIGIT) is also known as V-set and immunoglobulin domain-containing protein 9 (VSIG9), V-set and transmembrane domain-containing protein 3 (VSTM3),which belongs to single-pass type I membrane protein containing an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM). TIGIT is expressed at low levels on peripheral memory and regulatory CD4+ T-cells and NK cells and is up-regulated following activation of these cells (at protein level). TIGIT binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.