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ACVA Protein (AA 311-426)

ACVA 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
产品编号 ABIN4369364
发货至: 中国
  • 抗原 See all ACVA 蛋白
    ACVA (Activin A (ACVA))
    蛋白类型
    Recombinant
    生物活性
    Active
    产品特性
    AA 311-426
    宿主
    • 12
    • 3
    • 2
    资源
    • 5
    • 5
    • 2
    • 1
    HEK-293 Cells
    品牌
    ActiveMax®
    序列
    AA 311-426
    产品特性
    This protein carries no "tag". The protein has a calculated MW of 13 kDa. The protein migrates as 14 kDa under reducing (R) condition, and 27 kDa under non-reducing (NR) condition (SDS-PAGE).
    纯度
    >95 % as determined by SDS-PAGE.
    过滤
    0.22 μm filtered
    内毒素水平
    Less than 0.1 EU per μg by the LAL method.
  • 限制
    仅限研究用
  • 状态
    Lyophilized
    缓冲液
    0.056 % TFA in 60 % ACN
    注意事项
    Please avoid repeated freeze-thaw cycles.
    储存条件
    -20 °C
    储存方法
    No activity loss was observed after storage at: 4-8°C for 1 year in lyophilized state 4-8°C for 1 month under sterile conditions after reconstitution -20°C to -70°C for 3 months under sterile conditions after reconstitution
  • Basu, Bhattacharya, Ray, Mukhopadhyay, Chatterjee, Roy: "Invasion of ovarian cancer cells is induced byPITX2-mediated activation of TGF-β and Activin-A." in: Molecular cancer, Vol. 14, pp. 162, (2015) (PubMed).

  • 抗原
    ACVA (Activin A (ACVA))
    别名
    Activin A /INHBA (ACVA 产品)
    别名
    inhibin beta A subunit Protein, Inhba Protein
    背景
    Activin and inhibin are two closely related protein complexes that have almost directly opposite biological effects. Activin enhances FSH biosynthesis and secretion, and participates in the regulation of the menstrual cycle. Many other functions have been found to be exerted by activin, including roles in cell proliferation, differentiation, apoptosis, metabolism, homeostasis, immune response, wound repair, and endocrine function. Conversely inhibin down regulates FSH synthesis and inhibits FSH secretion.Activins are nonglycosylated homodimers or heterodimers of various β subunits (βA, βB, βC, and βE in mammals), while Inhibins are heterodimers of a unique α subunit and one of the β subunits. Activin A is a widely expressed homodimer of two βA chains. The βA subunit can also heterodimerize with a βB or βC subunit to form Activin AB and Activin AC, respectively. The 14 kDa mature human βA chain shares 100 % amino acid sequence identity with bovine, feline, mouse, porcine, and rat βA.
    分子量
    13.0 kDa
    途径
    Hormone Transport, Peptide Hormone Metabolism
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