alpha-Thrombin 蛋白
宿主: Pig
宿主: 猪
Native
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- 抗原 See all alpha-Thrombin products
- alpha-Thrombin
- 蛋白类型
- Native
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宿主
- Pig
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资源
- 猪
- 产品特性
- Porcine Thrombin
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
- Lyophilized Powder from 20mM PBS, pH 7.4 containing 0.9% NaCl.It is recommended to reconstitute the lyophilized Thrombin in sterile 18M omega cm H 2 O.
- 储存条件
- -20 °C
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- 抗原
- alpha-Thrombin
- 别名
- Thrombin (alpha-Thrombin 产品)
- 别名
- PT Protein, RPRGL2 Protein, THPH1 Protein, coagulation factor II, thrombin Protein, F2 Protein
- 背景
- Introduction: Thrombin enzyme (Activated Factor IIa) is an important clotting promoter that controls the transformation of soluble fibrinogen to insoluble active fibrin strands. Thrombin is a coagulation protein and a serine protease (EC 3.4.21.5) that catalyzes many coagulation-related reactions. Thrombin triggers factor-XI, factor-V, Factor-XIII and factor-VIII. Thrombin endorses platelet activation, using activation of protease-activated receptors on the platelet. As a result of its high proteolytic specificity, thrombin has become an important biochemical protein. The thrombin cleavage site (Leu-Val-Pro-Arg-Gly-Ser) is widely used in linker regions of recombinant fusion protein constructs. After the purification of the fusion protein, thrombin is used to cleave between the Arginine and Glycine residues of the cleavage site, efficiently removing the purification tag from the protein of interest with a high degree of specificity.
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