IL36A/IL1F6 蛋白
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- 抗原 See all IL36A/IL1F6 (IL1F6) 蛋白
- IL36A/IL1F6 (IL1F6) (Interleukin 1 Family, Member 6 (IL1F6))
- 蛋白类型
- Recombinant
- 生物活性
- Active
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宿主
- 小鼠
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资源
- 大肠杆菌（E. Coli）
- 应用范围
- Functional Studies (Func)
- 序列
- MNKEKELRAA SPSLRHVQDL SSRVWILQNN ILTAVPRKEQ TVPVTITLLP CQYLDTLETN RGDPTYMGVQ RPMSCLFCTK DGEQPVLQLG EGNIMEMYNK KEPVKASLFY HKKSGTTSTF ESAAFPGWFI AVCSKGSCPL ILTQELGEIF ITDFEMIVVH
- 产品特性
- Biological Activity: Fully biologically active when compared to standard. The specific activity determined by its ability in a functional ELISA. Immobilized rMuIL-36α at 1 μg/mL can bind recombinant murine IL-1 Rrp2 with a range of 0.15-5 μg/mL.
- 纯度
- >95 % as determined by SDS-PAGE and HPLC.
- 过滤
- 0.2 μm filtered
- Top Product
- Discover our top product IL1F6 蛋白
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Interleukin 1 Family, Member 6 (IL1F6) (Active) protein
IL1F6 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant >95 % as determined by reducing SDS-PAGE. Active
Interleukin 1 Family, Member 6 (IL1F6) (AA 1-158) protein (His tag)IL1F6 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE ELISA, WB
Interleukin 1 Family, Member 6 (IL1F6) (AA 1-160) protein (His tag)IL1F6 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE ELISA, WB
Interleukin 1 Family, Member 6 (IL1F6) (AA 1-158) protein (GST tag)IL1F6 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AP, AA
Interleukin 1 Family, Member 6 (IL1F6) (AA 1-61) protein (GST tag)IL1F6 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AP, AA
Interleukin 1 Family, Member 6 (IL1F6) protein (Myc-DYKDDDDK Tag)IL1F6 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
- PBS, pH 7.4, 5 % trehalose
- 储存条件
- -20 °C
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- 抗原
- IL36A/IL1F6 (IL1F6) (Interleukin 1 Family, Member 6 (IL1F6))
- 别名
- Il36a (IL1F6 产品)
- 别名
- Il1f6 Protein, Fil1 Protein, IL-1H1 Protein, IL1RP2 Protein, Il1f9 Protein, Il36a Protein, FIL1 Protein, FIL1(EPSILON) Protein, FIL1E Protein, IL-1F6 Protein, IL1(EPSILON) Protein, IL1F6 Protein, interleukin 36, alpha Protein, interleukin 1 family, member 6 (epsilon) Protein, interleukin 1 family, member 6 Protein, interleukin 36 alpha Protein, Il36a Protein, IL1F6 Protein, IL36A Protein, Il1f6 Protein
- 背景
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Relevance: Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response, similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T cells to drive tissue infiltration, cell maturation and cell proliferation. Induces the production of proinflammatory cytokines, including IL-12, Il-1 beta, IL-6, TNF-alpha and IL-23 in bone marrow-derived dendritic cells (BMDCs). Involved in dendritic cell maturation by stimulating the surface expression of CD80, CD86 and MHC class II. Induces the production of IFN-gamma, IL-4 and IL-17 by cultured CD4(+) T cells and splenocytes. May play a role in proinflammatory effects in the lung: induces the expression of CXCL1 and CXCL2 in the lung, and the expression of TNF-alpha, IL-36c, IL-1A, IL-1B, CXCL1 and CXCL2 in isolated splenic CD11c(+) alveolar macrophages. May be involved in T cell maturation by stimulating the surface expression of CD40 and modestly CD80 and CD86 in splenic CD11c(+) cells. May be involved in CD4(+) T cell proliferation. Induces NF-kappa B activation in macrophages. {ECO:0000269|PubMed:21860022, ECO:0000269|PubMed:21965679, ECO:0000269|PubMed:23029241, ECO:0000269|PubMed:24829417}.
Synonyms: FIL1 epsilon, IL-1 epsilon, Interleukin-1 family member 6, IL-1F6, Interleukin-1 homolog 1 - 分子量
- 18.0 kDa
- UniProt
- Q9JLA2
- 途径
- Cancer Immune Checkpoints
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