FYN 蛋白
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北京 101111
Quick Overview for FYN 蛋白 (ABIN2746630)
抗原
See all FYN 蛋白蛋白类型
宿主
资源
应用范围
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原理
- Purified Protein in ready-to-use SDS sample buffer.
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纯化方法
- Purified Protein
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FYN Oncogene Related To SRC, FGR, YES (FYN) (AA 1-482) protein (GST tag)
FYN 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP, KAA
FYN Oncogene Related To SRC, FGR, YES (FYN) (AA 41-190) protein (His-IF2DI Tag)FYN 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
FYN Oncogene Related To SRC, FGR, YES (FYN) (Transcript Variant 1) (Active) protein (Myc-DYKDDDDK Tag)FYN 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD, Func, PI Active
FYN Oncogene Related To SRC, FGR, YES (FYN) (Transcript Variant 2) protein (Myc-DYKDDDDK Tag)FYN 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
FYN Oncogene Related To SRC, FGR, YES (FYN) (Transcript Variant 3) protein (Myc-DYKDDDDK Tag)FYN 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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应用备注
- The sample is in ready-to-use buffer for application in SDS-PAGE and Western blotting.
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说明
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Synonyms: Proto-oncogene c-Fyn, p59, Src-like-kinase, SLK, Protooncogene Syn.P59-Fyn
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- For 5 applications, volume varies from 100-200 μL in reduced SDS-PAGE sample buffer.
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储存条件
- -20 °C
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储存方法
- -20 °C for long term storage
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- FYN (FYN Oncogene Related To SRC, FGR, YES (FYN))
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别名
- FYN
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背景
- Protein tyrosine kinases are large multigene families which are important mediators of the signaling transduction pathways, responsible for intracellular signal transduction. Tyrosine kinases are a diverse group of cell surface transmembrane proteins that act as receptors for cytokines, growth factors, hormones and other signaling molecules. Receptor tyrosine kinases are expressed in many cell types and play important roles in a wide variety of cellular processes, including growth, differentiation, angiogenesis, metabolism and apoptosis in response to external and internal stimuli. Over-expression and/or structural alteration of tyrosine kinase family members are associated to human cancers. Tumor cells use RTK transduction pathways to achieve tumor growth, angiogenesis and metastasis making it a target in approaches of cancer therapy. Fyn kinase is a 64 kDa protein and one of the 9 members of the Src family kinase (SFK) which are important in the regulation of growth and differentiation of eukaryotic cells. Src-family kinases transduce signals that are involved in the control of a variety of cellular processes, including proliferation, differentiation, motility, and adhesion. Synthesized and N-myristoylated Fyn protein is targeted to the plasma membrane, where it is palmitoylated. Fyn encodes a membraneassociated tyrosine kinase that is implicated in the control of cell growth and it plays a key role in T-cell antigen receptor (TCR) signaling. Dually acetylated Fyn clusters in caveolae-like membrane micro domains and interacts with a variety of other signaling molecules. Fyn's biological functions are diverse and include signaling via the T cell receptor, regulation of brain function and adhesion mediated signaling. It is required in brain development and mature brain function with important roles in the regulation of axon growth, axon guidance, and neurite extension. The human Fyn gene maps to chromosome 6q21 and encodes a 537 amino acid protein.
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分子量
- 64 kDa
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UniProt
- Q96AE9
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途径
- JAK/STAT Signaling, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Feeding Behaviour, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Activated T Cell Proliferation, Thromboxane A2 Receptor Signaling
抗原
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