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AADAT Protein (His tag)

AADAT 宿主: 人 宿主: 大肠杆菌(E. Coli) Recombinant >97 % (SDS-PAGE) SDS
产品编号 ABIN2745733
发货至: 中国
  • 抗原 See all AADAT 蛋白
    AADAT (Aminoadipate Aminotransferase (AADAT))
    蛋白类型
    Recombinant
    宿主
    • 6
    • 1
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    资源
    • 3
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    大肠杆菌(E. Coli)
    标记
    This AADAT protein is labelled with His tag.
    应用范围
    SDS-PAGE (SDS)
    交叉反应
    产品特性
    Human full-length KAT II is fused at the N-terminus to a His-tag.
    纯度
    >97 % (SDS-PAGE)
    Top Product
    Discover our top product AADAT 蛋白
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    Lot specific
    缓冲液
    In 50 mM phosphate buffer pH 8.0, containing 50 mM sodium chloride and 40μM pyridoxal 5'-phosphate (PLP).
    储存条件
    -20 °C,-80 °C
    储存方法
    Short Term Storage: -20°C
    Long Term Storage: -80°C
    Stable for at least 6 months after receipt when stored at -80°C.
    有效期
    6 months
  • 抗原
    AADAT (Aminoadipate Aminotransferase (AADAT))
    别名
    Kynurenine Aminotransferase II (AADAT 产品)
    别名
    KAT2 Protein, KATII Protein, AI875679 Protein, Aadt Protein, Kat2 Protein, mKat-2 Protein, MGC80030 Protein, kat2 Protein, katii Protein, aminoadipate aminotransferase Protein, aminoadipate aminotransferase S homeolog Protein, AADAT Protein, Aadat Protein, aadat.S Protein, aadat Protein
    背景
    Kynurenine aminotransferases (KATs) are pyridoxal-5'-phosphate-dependent enzymes that catalyze the conversion of L-kynurenine into kynurenic acid, a neuroactive metabolite whose unbalancing is associated with a number of brain disorders. Biochemical and structural investigations revealed that L-kynurenine (L-KYN) recognition by hKAT II is achieved by exploiting structural features that are peculiar of this isoform, thus offering the possibility to select/design inhibitor molecules specifically targeting hKAT II to be used as modulators of kynurenic acid synthesis in the CNS. hKAT II is one of the aminotransferases involved in the pyridoxal 5'-phosphate (PLP)-dependent irreversible transamination of L-kynurenine (L-KYN) to kynurenic acid (KYNA) in the central nervous system. When assayed in vitro the protein also displays beta-elimination activity.
    分子量
    ~49.8kDa
    NCBI登录号
    NP_872603
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