NUDT1 Protein (Transcript Variant 3A) (Myc-DYKDDDDK Tag)
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- 抗原 See all NUDT1 蛋白
- NUDT1 (Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 1 (NUDT1))
- 蛋白类型
- Recombinant
- 产品特性
- Transcript Variant 3A
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This NUDT1 protein is labelled with Myc-DYKDDDDK Tag.
- 应用范围
- Antibody Production (AbP), Standard (STD)
- 产品特性
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- Recombinant human NUDT1 (transcript variant 3A) protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
- 纯度
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
- Top Product
- Discover our top product NUDT1 蛋白
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- 应用备注
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays - 说明
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The tag is located at the C-terminal.
- 限制
- 仅限研究用
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- 浓度
- 50 μg/mL
- 缓冲液
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
- 储存条件
- -80 °C
- 储存方法
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- 抗原
- NUDT1 (Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 1 (NUDT1))
- 别名
- Nudt1 (NUDT1 产品)
- 别名
- mutT Protein, nudT1 Protein, MTH1 Protein, Mth1 Protein, 7,8-dihydro-8-oxoguanine triphosphatase Protein, nudix hydrolase 1 Protein, nudix (nucleoside diphosphate linked moiety X)-type motif 1 Protein, mth1 Protein, Tsp_07498 Protein, nudt1 Protein, 8odp Protein, NUDT1 Protein, Nudt1 Protein
- 背景
- Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A single-nucleotide polymorphism that results in the production of an additional, longer isoform (p26) has been described.
- 分子量
- 17.8 kDa
- NCBI登录号
- NP_945188
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