BRD7 Protein (AA 129-236) (GST tag)
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- 抗原 See all BRD7 蛋白
- BRD7 (Bromodomain Containing 7 (BRD7))
- 蛋白类型
- Recombinant
- 产品特性
- AA 129-236
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宿主
- 人
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资源
- 大肠杆菌（E. Coli）
- 标记
- This BRD7 protein is labelled with GST tag.
- 应用范围
- Binding Studies (Bind), Screening Assay (ScA)
- 产品特性
- The peptide corresponding to amino acids 129 - 236 that contains the bromodomain sequences of BRD7 (accession number NM_013263.4) was expressed in E. coli and contains an N-terminal GST tag with a molecular weight of 39 kDa. It shows binding specificity for acetylated H3K9, H3K14, H4K8, H4K12 and H4K16.
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- Discover our top product BRD7 蛋白
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Bromodomain Containing 7 (BRD7) (AA 1-651) protein (GST tag)
BRD7 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AA, AP
Bromodomain Containing 7 (BRD7) (AA 129-236) protein (His tag,DYKDDDDK Tag)BRD7 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant
Bromodomain Containing 7 (BRD7) protein (Myc-DYKDDDDK Tag)BRD7 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- 应用备注
- Recombinant BRD7 (129-236), GST-tag is suitable for use in binding assays, inhibitor screening, and selectivity profiling.
- 限制
- 仅限研究用
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- 注意事项
- Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
- 储存条件
- -80 °C
- 储存方法
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation.
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- 抗原
- BRD7 (Bromodomain Containing 7 (BRD7))
- 别名
- BRD7 (BRD7 产品)
- 别名
- zgc:66347 Protein, wu:fc95f02 Protein, MGC79478 Protein, BRD7 Protein, BP75 Protein, CELTIX1 Protein, NAG4 Protein, Ptpn13ip Protein, bromodomain containing 7 L homeolog Protein, bromodomain containing 7 Protein, brd7.L Protein, brd7 Protein, BRD7 Protein, Brd7 Protein
- 背景
- Bromodomain-containing protein 7 (BRD7) belongs to the BET subclass of proteins, which are characterized by two N-terminal bromodomains and one ET (Extra Terminal) domain. BRDs associate with chromatin through their bromodomains that recognize acetylated histone lysine residues. Bromodomains function as 'readers' of these epigenetic histone marks and regulate chromatin structure and gene expression by linking associated proteins to the acetylated nucleosomal targets. The ET domain functions as a protein binding motif and exerts atypical serine-kinase activity. The BET family consists of at least four members in mouse and human, BRD2 (also referred to as FSRG1, RING3), BRD3 (FSRG2, ORFX), BRD4 (FSRG4, MCAP/HUNK1), and BRDT (FSRG3, BRD6). BRD7 interacts with several proteins, including DVL1, PTPN13, IRF2 and HNRPUL1 and functions in the regulation of transcriptional activation and chromatin remodeling. Specifically, BRD7 has been shown to bind dishevelled-1 (DVL1) and enhance Wnt signaling via inhibition of GSK3β. BRD7 also associates with histones and E1B-AP5. In particular, it binds acetylated histone peptides, most notably H3 peptide acetylated at Lys14. BRD7 also inhibits G1-S progression by transcriptional regulation of molecules in the Ras and Rb pathways. BRD7 also suppresses tumorigenicity through binding and acetylation of p53 that results in efficient recruitment of p53 to target promoters and subsequent oncogene-induced senescence.
- 分子量
- 39 kDa
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