CEACAM1 蛋白
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- 抗原 See all CEACAM1 蛋白
- CEACAM1 (Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1))
- 蛋白类型
- Recombinant
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宿主
- 人
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资源
- 大肠杆菌（E. Coli）
- 应用范围
- Western Blotting (WB), SDS-PAGE (SDS)
- 纯度
- >95 %
- Top Product
- Discover our top product CEACAM1 蛋白
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Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1) protein (His tag)
CEACAM1 宿主: 人 宿主: HEK-293 Cells Recombinant > 95% as determined by Tris-Bis PAGE,> 95% as determined by HPLC
Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1) (AA 35-428) protein (His tag)CEACAM1 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1) (AA 35-143) protein (His tag)CEACAM1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1) (AA 1-464) protein (GST tag)CEACAM1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1) (AA 305-414) protein (GST tag)CEACAM1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1) (AA 1-468) protein (GST tag)CEACAM1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1) (AA 35-428) protein (His tag)CEACAM1 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.
Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1) protein (His tag)CEACAM1 宿主: 大鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE
Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1) (AA 35-428) protein (His tag,AVI tag,Biotin)CEACAM1 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by reduced SDS-PAGE.
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- 20 mM Phosphate buffer pH 7.5, 0.5M sodium chloride, 1.5Mm EDTA, 10 % glycerol.
- 储存条件
- -20 °C
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- 抗原
- CEACAM1 (Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1))
- 别名
- CEACAM 1 (CEACAM1 产品)
- 别名
- BGP Protein, BGP1 Protein, BGPI Protein, CD66e Protein, CEA Protein, zeh0068 Protein, hm:zeh0068 Protein, CEACAM8 Protein, CEACAM1 Protein, MGC142545 Protein, BGPR Protein, Bgp Protein, CD66a Protein, Ccam1 Protein, Bgp1 Protein, C-CAM Protein, Cc1 Protein, Cea-1 Protein, Cea-7 Protein, Cea1 Protein, Cea7 Protein, Hv-2 Protein, Hv2 Protein, MHVR Protein, MHVR1 Protein, Mhv-1 Protein, bb-1 Protein, mCEA1 Protein, mmCGM1 Protein, mmCGM1a Protein, mmCGM2 Protein, carcinoembryonic antigen related cell adhesion molecule 1 Protein, carcinoembryonic antigen related cell adhesion molecule 5 Protein, carcinoembryonic antigen-related cell adhesion molecule 1 Protein, carcinoembryonic antigen-related cell adhesion molecule 6 Protein, CEACAM1 Protein, CEACAM5 Protein, ceacam1 Protein, Ceacam1 Protein, LOC101103343 Protein
- 背景
- The carcinoembryonic antigen (CEA) family is composed of 29 genes tandemly arranged on chromosome 19q13.2. Based on nucleotide homologies, these genes are classified into 2 major subfamilies, the CEACAM and the pregnancy-specific glycoprotein (PSG) subgroups. The CEACAM-encoded proteins include CEA, CEACAM1, and other CEA gene members (1). CEACAM1 (Carcinoembryonic antigen related cell adhesion molecule 1, also BGP1, CD66a), is involved in the regulation of important biological processes, such asinsulin homeostasis (2) , angiogenesis (3), and modulation of the immune response (4). Expression of CEACAM1 is associated with the progression of malignancy and metastatic spread in a large array of cancer tissues which include melanoma, Non Small Cell Lung Carcinoma (NSCLC) bladder, prostate, thyroid, breast, colon and gastric carcinomas (5). In addition, CEACAM1 has also been identified as receptors for host-specific viruses and bacteria in mice and humans such as Neisseria, Haemophilus influenzae, Moraxella catarrhalis and mouse hepatitis virus (MHV) (6,7). The binding of Opa (the neisserial colony opacity associated) proteins occurs at the non-glycosylated face of the N-domain of CEACAM1 (8), heterophilic adhesion facilitates bacterial colonization of the gut and bacterial phagocytosis by neutrophilis, and is involved in the granulocytes migration during inflammatory responses. The N-terminal domain of CEACAM1 has been implicated also in mediating homophilic adhesion (9). This is an important factor for the embryonic organization of the intestinal epithelium and hepatocytes in the liver, in placental trophoblasts, during muscle and tooth development and vascularisation of the central nervous system, in angiogenesis and in the negative regulation of cell proliferation.
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