Coxsackie Adenovirus Receptor (CXADR)
(Coxsackie Virus and Adenovirus Receptor (CXADR))
蛋白类型
Recombinant
产品特性
AA 20-237
宿主
人
资源
HEK-293 Cells
标记
This Coxsackie Adenovirus Receptor protein is labelled with His tag.
序列
AA 20-237
产品特性
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 24.9 kDa. The protein migrates as 35 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C-8 °C), After reconstitution under sterile conditions for 1 month (4 °C-8 °C) or 3 months (-20 °C to -70 °C).
抗原
Coxsackie Adenovirus Receptor (CXADR)
(Coxsackie Virus and Adenovirus Receptor (CXADR))
Coxsackie virus and adenovirus receptor (CXADR) is also known as CAR, is a type I transmembrane glycoprotein for group B coxsackie viruses and subgroup C adenoviruses, and belongs to the CTX family of the Ig superfamily. CAR is strongly expressed in the developing central nervous system. It functions as a homophilic and also as a heterophilic cell adhesion molecule through its interactions with extracellular matrix glycoproteins such as: fibronectin, agrin, laminin-1 and tenascin-R. Human CXADR protein contains a signal sequence, a extracellular domain (ECD) with a V- type (D1) and a C2- type (D2) Ig-like domain, a transmembrane segment and a intracellular domain. D1 is thought to be responsible for homodimer formation in trans within tight junctions, and is necessary and sufficient for adenovirus binding. Variants of CXADR are attached to the cell membrane by a GPI- anchor.