This protein carries a GST tag at the N-terminus. The protein has a calculated MW of 50.5 kDa. The protein migrates as 46 kDa under reducing (R) condition (SDS-PAGE).
BCL2L1
宿主: 人
宿主: 大肠杆菌(E. Coli)
Recombinant
> 85 % as determined by reducing SDS-PAGE.
Active
限制
仅限研究用
状态
Lyophilized
缓冲液
20 mM Tris, 100 mM NaCl, pH 7.5 with 10 mM GSH
注意事项
Please avoid repeated freeze-thaw cycles.
储存条件
-20 °C
储存方法
No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Bcl-2-like protein 1 (BCL2L1), is also known as Apoptosis regulator Bcl-X (Bcl-XL). BCL2L1 / Bcl-XL is a homodimer protein and belongs to the Bcl-2 family. BCL2L1 is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. BCL2L1 is a potent inhibitor of cell death. BCL2L1 Inhibits activation of caspases. BCL2L1 appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. BCL2L1 / Bcl-XL also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.